2. Gene
  3. Edn3 - endothelin 3 Gene

Edn3 - endothelin 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as ls; ET-3; PPET3; tmgc48

Gene ID: 13616 | Gene type: protein coding

About Edn3

Summary

This gene is a member of the endothelin family whose members encode proteins that act on G protein-coupled receptors. Endothelins are produced as large prepropolypeptide precursors that undergo a first cleavage by a subtilisin serine protease to form an inactive intermediate, which in turn is cleaved again by endothelin-converting enzyme 1 (ECE-1) to yield the active 21 amino acid peptide. This gene encodes a protein which is expressed in neural crest cells (NCC), binds to Endothelin Receptor b (Ednrb) and plays an essential role in the development of NCC-derived cell lineages including melanocytes and enteric neurons. Mutations in this gene are associated with terminal aganglionosis and white spotted coat in mice and Hirschsprung's disease and Waardenburg syndrome in humans. [provided by RefSeq, Apr 2013]

Edn3 Products(2)

mRNA Protein Name
NM_007903.5 NP_031929.1 endothelin-3 preproprotein
NM_007903.5 NP_031929.1 endothelin-3 preproprotein
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in axon extension IDA
IDA: Inferred from direct assay
18401410 MGI
involved in axon guidance IMP
IMP: Inferred from mutant phenotype
18401410 MGI
acts upstream of cell population proliferation IDA
IDA: Inferred from direct assay
11401406 MGI
acts upstream of establishment of localization in cell IGI
IGI: Inferred from genetic interaction
19544475 MGI
acts upstream of or within intracellular calcium ion homeostasis IGI
IGI: Inferred from genetic interaction
23122227 MGI
acts upstream of or within intracellular magnesium ion homeostasis IGI
IGI: Inferred from genetic interaction
23122227 MGI
acts upstream of or within melanocyte differentiation IDA
IDA: Inferred from direct assay
9012511 MGI
acts upstream of or within neural crest cell migration IMP
IMP: Inferred from mutant phenotype
9624616 MGI
acts upstream of or within neuron differentiation IMP
IMP: Inferred from mutant phenotype
9624616 MGI
involved in neuron projection development IDA
IDA: Inferred from direct assay
24875861 MGI
acts upstream of or within positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
11401406 MGI
acts upstream of or within positive regulation of potassium ion transmembrane transport IGI
IGI: Inferred from genetic interaction
19544475 MGI
acts upstream of potassium ion transmembrane transport IGI
IGI: Inferred from genetic interaction
19544475 MGI
acts upstream of or within regulation of cell migration IMP
IMP: Inferred from mutant phenotype
14138974 MGI
acts upstream of or within regulation of developmental pigmentation IMP
IMP: Inferred from mutant phenotype
14138974 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

endothelin-3

preproendothelin-3

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04165 EDN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Edn3 NCBI NCBI:1908