Ehd1 - EH-domain containing 1 Gene

Also Known as Past1; RME-1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 13660

Summary

Predicted to enable identical protein binding activity and small GTPase binding activity. Involved in several processes, including Cholesterol homeostasis; low-density lipoprotein particle clearance; and positive regulation of Cholesterol storage. Acts upstream of or within endocytosis and endosomal transport. Located in several cellular components, including cytoplasmic vesicle; lipid droplet; and platelet dense tubular network membrane. Is expressed in several structures, including branchial arch; limb bud; musculoskeletal system; reproductive system; and retina layer. Orthologous to human EHD1 (EH domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Ehd1 Products (1)

mRNA	Protein	Name
NM_010119.5	NP_034249.1	EH domain-containing protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12121420	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in cholesterol homeostasis	IMP IMP: Inferred from mutant phenotype	17451652	MGI
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	25686250	MGI
acts upstream of or within endocytosis	IDA IDA: Inferred from direct assay	15247266	MGI
acts upstream of or within endosomal transport	IDA IDA: Inferred from direct assay	11389441	MGI
involved in low-density lipoprotein particle clearance	IMP IMP: Inferred from mutant phenotype	17451652	MGI
involved in positive regulation of cholesterol storage	IMP IMP: Inferred from mutant phenotype	17451652	MGI
involved in positive regulation of endocytic recycling	IMP IMP: Inferred from mutant phenotype	21177873	MGI
involved in positive regulation of myoblast fusion	IMP IMP: Inferred from mutant phenotype	21177873	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in early endosome	IDA IDA: Inferred from direct assay	11389441	MGI
located in endocytic vesicle	IDA IDA: Inferred from direct assay	12121420	MGI
located in endosome	IDA IDA: Inferred from direct assay	15247266	MGI
located in lipid droplet	IDA IDA: Inferred from direct assay	17451652	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	20489164	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15247266	MGI
located in platelet dense tubular network membrane	IDA IDA: Inferred from direct assay	17451652	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
EH domain-containing protein 1	PAST homolog 1 mPAST1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04221	EHD1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ehd1	NCBI	NCBI:10938