UNC5D - unc-5 netrin receptor D Gene

Also Known as Unc5h4; PRO34692

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 137970

About UNC5D

Cytogenetic location: 8p12 Genomic coordinates (GRCh38): 8:35,235,475-35,796,540 (from NCBI)

This gene has 7 transcripts (splice variants), 279 orthologues and 4 paralogues. Biased expression in brain (RPKM 2.7), duodenum (RPKM 2.4) and 8 other tissues.

Summary

Predicted to enable netrin receptor activity. Involved in cell-cell adhesion via plasma-membrane adhesion molecules. Predicted to be located in cell surface and plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

UNC5D Products (3)

mRNA Protein Name
NM_001322818.2 NP_001309747.1 netrin receptor UNC5D isoform 2
NM_001410918.1 NP_001397847.1 netrin receptor UNC5D isoform 3 precursor
NM_080872.4 NP_543148.2 netrin receptor UNC5D isoform 1 precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in cell-cell adhesion via plasma-membrane adhesion molecules IDA
IDA: Inferred from direct assay
26235030 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UNC5D Protein Structure

I-set

I-set: Immunoglobulin I-set domain (160 - 247)

TSP_1

TSP_1: Thrombospondin type 1 domain (256 - 302)

TSP_1

TSP_1: Thrombospondin type 1 domain (313 - 359)

ZU5

ZU5: ZU5 domain (542 - 641)

Death

Death: Death domain (860 - 929)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 953 a.a.
Protein Preferred Names Protein Names

netrin receptor UNC5D

  • netrin receptor Unc5h4

Related Diseases

Diseases Alias
Anisometropia
Severe Congenital Neutropenia 4

  • Autosomal Recessive Severe Congenital Neutropenia Due To G6pc3 Deficiency

  • Scn4

  • Severe Congenital Neutropenia-Pulmonary Hypertension-Superficial Venous Angiectasis Syndrome

  • Dursun Syndrome

  • Severe Congenital Neutropenia Type 4
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15474 UNC5D Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus UNC5D MGD MGI:2389364
Felis catus UNC5D VGNC VGNC:66832
Rattus norvegicus UNC5D RGD RGD:1309245
Macaca mulatta UNC5D VGNC VGNC:79158
Bos taurus UNC5D VGNC VGNC:36674
Canis familiaris UNC5D VGNC VGNC:48143
Others UNC5D NCBI