NACC2 - NACC family member 2 Gene

Also Known as RBB; BEND9; NAC-2; BTBD14; BTBD31; BTBD14A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 138151

About NACC2

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:136,006,537-136,095,289 (from NCBI)

This gene has 3 transcripts (splice variants), 257 orthologues and 28 paralogues. Ubiquitous expression in brain (RPKM 17.8), fat (RPKM 7.6) and 24 other tissues.

Summary

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein homodimerization activity. Involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage; and protein homooligomerization. Located in chromatin; mitochondrion; and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

NACC2 Products (1)

mRNA Protein Name
NM_144653.5 NP_653254.1 nucleus accumbens-associated protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
22926524 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
22926524 GOA
enables histone deacetylase binding IPI
IPI: Inferred from physical interaction
22926524 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22926524 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
22926524 GOA
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
22926524 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
22926524 GOA
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
22926524 GOA
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
22926524 GOA
involved in positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage IDA
IDA: Inferred from direct assay
22926524 GOA
involved in protein homooligomerization IDA
IDA: Inferred from direct assay
22926524 GOA
involved in protein-containing complex localization IDA
IDA: Inferred from direct assay
22926524 GOA
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
22926524 GOA
located in nucleus IDA
IDA: Inferred from direct assay
22926524 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NACC2 Protein Structure

BTB

BTB: BTB/POZ domain (20 - 116)

BEN

BEN: BEN domain (374 - 446)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 587 a.a.
Protein Preferred Names Protein Names

nucleus accumbens-associated protein 2

  • BEN domain containing 9

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09003 NACC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris NACC2 VGNC VGNC:43604
Bos taurus NACC2 VGNC VGNC:31862
Rattus norvegicus NACC2 RGD RGD:1309292
Macaca mulatta NACC2 VGNC VGNC:75013
Mus musculus NACC2 MGD MGI:1915241
Felis catus NACC2 VGNC VGNC:63709
Others NACC2 NCBI