PIP5KL1 - phosphatidylinositol-4-phosphate 5-kinase like 1 Gene

Also Known as PIPKH

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 138429

About PIP5KL1

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:127,920,881-127,930,777 (from NCBI)

This gene has 12 transcripts (splice variants), 226 orthologues and 6 paralogues. Low expression observed in reference dataset.

Summary

PIP5KL1 is a phosphoinositide kinase-like protein that lacks intrinsic lipid kinase activity but associates with type I PIPKs (see PIP5K1A; MIM 603275) and may play a role in localization of PIPK activity (Chang et al., 2004 [PubMed 14701839]).[supplied by OMIM, Jun 2009]

PIP5KL1 Products (2)

mRNA Protein Name
NM_001135219.2 NP_001128691.1 phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform 1
NM_173492.2 NP_775763.1 phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform 2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in negative regulation of cell migration IMP
IMP: Inferred from mutant phenotype
19680787 GOA
involved in negative regulation of mitochondrial membrane potential IDA
IDA: Inferred from direct assay
16751333 GOA
involved in negative regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
19680787 GOA
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
16751333 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIP5KL1 Protein Structure

PIP5K

PIP5K: Phosphatidylinositol-4-phosphate 5-Kinase (132 - 391)

  • 0
  • 100
  • 200
  • 300
  • 394 a.a.
Protein Preferred Names Protein Names

phosphatidylinositol 4-phosphate 5-kinase-like protein 1

  • PI(4)P 5-kinase-like protein 1

Related Diseases

Diseases Alias
Chronic Closed-Angle Glaucoma

  • Anatomical Narrow Angle Glaucoma

  • Chronic Angle-Closure Glaucoma

  • Chronic Narrow Angle Glaucoma

  • Secondary Angle-Closure Glaucoma - Synechial
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10569 PIP5KL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PIP5KL1 VGNC VGNC:64184
Rattus norvegicus PIP5KL1 RGD RGD:1597527
Bos taurus PIP5KL1 VGNC VGNC:32913
Mus musculus PIP5KL1 MGD MGI:2448520
Canis familiaris PIP5KL1 VGNC VGNC:44577
Others PIP5KL1 NCBI