Eps8 - epidermal growth factor receptor pathway substrate 8 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13860

Summary

Enables actin binding activity and small GTPase binding activity. Involved in several processes, including Rac protein signal transduction; actin filament organization; and barbed-end actin filament capping. Acts upstream of or within several processes, including actin Cytoskeleton reorganization; behavioral response to ethanol; and cellular response to Leukemia Inhibitory Factor. Located in several cellular components, including brush border; ruffle membrane; and stereocilium tip. Part of NMDA selective glutamate receptor complex. Is expressed in several structures, including adrenal gland; alimentary system; bone; brain; and metanephros. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 102. Orthologous to human EPS8 (epidermal growth factor receptor pathway substrate 8). [provided by Alliance of Genome Resources, Apr 2022]

Eps8 Products (10)

mRNA Protein Name
NM_001271587.2 NP_001258516.1 epidermal growth factor receptor kinase substrate 8 isoform 2
NM_001271588.2 NP_001258517.1 epidermal growth factor receptor kinase substrate 8 isoform 1
NM_001271589.2 NP_001258518.1 epidermal growth factor receptor kinase substrate 8 isoform 3
NM_001271595.2 NP_001258524.1 epidermal growth factor receptor kinase substrate 8 isoform 1
NM_001409747.1 NP_001396676.1 epidermal growth factor receptor kinase substrate 8 isoform 1
NM_001409750.1 NP_001396679.1 epidermal growth factor receptor kinase substrate 8 isoform 4
NM_001409751.1 NP_001396680.1 epidermal growth factor receptor kinase substrate 8 isoform 4
NM_001409752.1 NP_001396681.1 epidermal growth factor receptor kinase substrate 8 isoform 3
NM_001409757.1 NP_001396686.1 epidermal growth factor receptor kinase substrate 8 isoform 5
NM_007945.4 NP_031971.2 epidermal growth factor receptor kinase substrate 8 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin binding IDA
IDA: Inferred from direct assay
11524436 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9010225 MGI
enables small GTPase binding IDA
IDA: Inferred from direct assay
11524436 MGI
Biological Process GO Annotation Evidence References Source
involved in Rac protein signal transduction IDA
IDA: Inferred from direct assay
11524436 MGI
involved in actin crosslink formation IDA
IDA: Inferred from direct assay
20532239 MGI
involved in actin crosslink formation IMP
IMP: Inferred from mutant phenotype
17115031 MGI
acts upstream of or within actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
17018287 MGI
involved in actin filament bundle assembly IDA
IDA: Inferred from direct assay
20532239 MGI
acts upstream of or within actin filament bundle assembly IGI
IGI: Inferred from genetic interaction
19208628 MGI
involved in actin filament bundle assembly IMP
IMP: Inferred from mutant phenotype
17115031 MGI
involved in actin polymerization-dependent cell motility IDA
IDA: Inferred from direct assay
15558031 MGI
acts upstream of or within adult locomotory behavior IMP
IMP: Inferred from mutant phenotype
17018287 MGI
involved in barbed-end actin filament capping IDA
IDA: Inferred from direct assay
15558031 MGI
involved in barbed-end actin filament capping IMP
IMP: Inferred from mutant phenotype
23314863 MGI
acts upstream of or within behavioral response to ethanol IMP
IMP: Inferred from mutant phenotype
17018287 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
involved in dendritic cell migration IMP
IMP: Inferred from mutant phenotype
21835647 MGI
involved in exit from mitosis IMP
IMP: Inferred from mutant phenotype
23314863 MGI
involved in regulation of actin filament length IMP
IMP: Inferred from mutant phenotype
21236676 MGI
involved in regulation of cell shape IMP
IMP: Inferred from mutant phenotype
17115031 MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels EXP
EXP: Inferred from Experiment
27450093 MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
IDA: Inferred from direct assay
27450093 MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IEP
IEP: Inferred from expression pattern
27450093 MGI
Cellular Component GO Annotation Evidence References Source
part of NMDA selective glutamate receptor complex IDA
IDA: Inferred from direct assay
17018287 MGI
located in brush border IDA
IDA: Inferred from direct assay
22114352 MGI
located in cell cortex IDA
IDA: Inferred from direct assay
11524436 MGI
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
27450093 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
27450093 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
27450093 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
17018287 MGI
located in ruffle membrane IDA
IDA: Inferred from direct assay
11524436 MGI
located in stereocilium IDA
IDA: Inferred from direct assay
21236676 MGI
located in stereocilium bundle IDA
IDA: Inferred from direct assay
23918390 MGI
located in stereocilium tip IDA
IDA: Inferred from direct assay
23918390 MGI
located in synapse IDA
IDA: Inferred from direct assay
17018287 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

epidermal growth factor receptor kinase substrate 8

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04454 EPS8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P10994 Eps8 peptide 327 / Unkown
HY-P10995 TAT-327 / Unkown
HY-P11076 CP-EPS8-NLS Inhibitor / Unkown
HY-RS04455 EPS8L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04456 EPS8L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04457 EPS8L3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20154 Eps8l1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26658 Eps8l1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eps8 NCBI NCBI:2059