Epx - eosinophil peroxidase Gene

Also Known as EPO

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13861

Summary

This gene encodes a member of the peroxidase superfamily of Enzymes that is produced by eosinophils and plays a critical role in eliminating tissue-invasive parasites. The encoded preproprotein undergoes proteolytic processing to generate a heterodimeric enzyme that forms a predominant component of the intracellular granules of eosinophils. Mice lacking the encoded protein exhibit resistance to ulcerative colitis induced by dextran sulfate. [provided by RefSeq, Jul 2016]

Epx Products (1)

mRNA Protein Name
NM_007946.2 NP_031972.2 eosinophil peroxidase preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables peroxidase activity IDA
IDA: Inferred from direct assay
8773591 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within defense response to nematode IMP
IMP: Inferred from mutant phenotype
16926417 MGI
acts upstream of or within eosinophil migration IMP
IMP: Inferred from mutant phenotype
16926417 MGI
acts upstream of interleukin-10 production IMP
IMP: Inferred from mutant phenotype
16926417 MGI
acts upstream of interleukin-4 production IMP
IMP: Inferred from mutant phenotype
16926417 MGI
acts upstream of interleukin-5 production IMP
IMP: Inferred from mutant phenotype
16926417 MGI
acts upstream of macrophage cytokine production IMP
IMP: Inferred from mutant phenotype
16926417 MGI
acts upstream of or within negative regulation of interleukin-10 production IMP
IMP: Inferred from mutant phenotype
16926417 MGI
acts upstream of or within negative regulation of interleukin-5 production IMP
IMP: Inferred from mutant phenotype
16926417 MGI
acts upstream of or within negative regulation of macrophage cytokine production IMP
IMP: Inferred from mutant phenotype
16926417 MGI
acts upstream of or within positive regulation of interleukin-4 production IMP
IMP: Inferred from mutant phenotype
16926417 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

eosinophil peroxidase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04459 EPX Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Epx NCBI NCBI:8288