Esx1 - extraembryonic, spermatogenesis, homeobox 1 Gene

Mus musculus

Also known as Spx1

Gene ID: 13984 | Gene type: protein coding

About Esx1

Summary

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within labyrinthine layer blood vessel development; labyrinthine layer morphogenesis; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; extraembryonic component; genitourinary system; hindlimb phalanx; and viscerocranium. Orthologous to human ESX1 (ESX homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Esx1 Products(1)

mRNA	Protein	Name
NM_007957.2	NP_031983.2	homeobox protein ESX1

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within blood vessel development	IMP IMP: Inferred from mutant phenotype	9806555	MGI
acts upstream of or within labyrinthine layer blood vessel development	IMP IMP: Inferred from mutant phenotype	9806555	MGI
acts upstream of or within labyrinthine layer morphogenesis	IMP IMP: Inferred from mutant phenotype	9806555	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19796622	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	19796622	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

homeobox protein ESX1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04547	ESX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Esx1	NCBI	NCBI:80712

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