Ext2 - exostosin glycosyltransferase 2 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14043

Summary

Enables acetylglucosaminyltransferase activity; glucuronosyltransferase activity; and protein homodimerization activity. Acts upstream of or within with a positive effect on gene expression; protein N-linked glycosylation; and sulfation. Acts upstream of or within several processes, including heparan sulfate proteoglycan biosynthetic process; heparin biosynthetic process; and sodium ion homeostasis. Located in Golgi apparatus and endoplasmic reticulum. Is expressed in several structures, including alimentary system; central nervous system; ear; genitourinary system; and respiratory system. Used to study hereditary multiple exostoses. Orthologous to human EXT2 (exostosin Glycosyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]

Ext2 Products (3)

mRNA Protein Name
NM_001355075.1 NP_001342004.1 exostosin-2 isoform 1
NM_001355076.1 NP_001342005.1 exostosin-2 isoform 3
NM_010163.3 NP_034293.2 exostosin-2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity IGI
IGI: Inferred from genetic interaction
10639137 MGI
enables acetylglucosaminyltransferase activity IDA
IDA: Inferred from direct assay
10639137 MGI
enables glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity IGI
IGI: Inferred from genetic interaction
10639137 MGI
enables glucuronosyltransferase activity IDA
IDA: Inferred from direct assay
10639137 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18337501 MGI
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
10639137 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to fibroblast growth factor stimulus IMP
IMP: Inferred from mutant phenotype
21310272 MGI
acts upstream of or within chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
16236767 MGI
acts upstream of or within endochondral bone morphogenesis IGI
IGI: Inferred from genetic interaction
21310272 MGI
acts upstream of or within fluid transport IGI
IGI: Inferred from genetic interaction
31365577 MGI
acts upstream of or within positive effect gene expression IDA
IDA: Inferred from direct assay
18337501 MGI
acts upstream of or within positive effect gene expression IMP
IMP: Inferred from mutant phenotype
18337501 MGI
acts upstream of or within heart contraction IGI
IGI: Inferred from genetic interaction
31365577 MGI
involved in heparan sulfate proteoglycan biosynthetic process IGI
IGI: Inferred from genetic interaction
10639137 MGI
acts upstream of or within heparan sulfate proteoglycan biosynthetic process IMP
IMP: Inferred from mutant phenotype
16236767 MGI
acts upstream of or within heparin biosynthetic process IGI
IGI: Inferred from genetic interaction
21310272 MGI
acts upstream of or within mesoderm formation IMP
IMP: Inferred from mutant phenotype
16236767 MGI
acts upstream of or within multicellular organismal-level water homeostasis IGI
IGI: Inferred from genetic interaction
31365577 MGI
acts upstream of or within positive effect protein N-linked glycosylation IDA
IDA: Inferred from direct assay
18337501 MGI
acts upstream of or within regulation of blood pressure IGI
IGI: Inferred from genetic interaction
31365577 MGI
acts upstream of or within sodium ion homeostasis IGI
IGI: Inferred from genetic interaction
31365577 MGI
acts upstream of or within positive effect sulfation IDA
IDA: Inferred from direct assay
18337501 MGI
acts upstream of or within vasodilation IGI
IGI: Inferred from genetic interaction
31365577 MGI
Cellular Component GO Annotation Evidence References Source
is active in Golgi apparatus IDA
IDA: Inferred from direct assay
10639137 MGI
located in Golgi apparatus IDA
IDA: Inferred from direct assay
10639137 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
10639137 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

exostosin-2

  • exostoses (multiple) 2

  • glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase

  • multiple exostoses protein 2 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04608 EXT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ext2 NCBI NCBI:2132