2. Gene
  3. Strc - stereocilin Gene

Strc - stereocilin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as DFNB16

Gene ID: 140476 | Gene type: protein coding

About Strc

Summary

Involved in auditory receptor cell stereocilium organization. Acts upstream of or within detection of mechanical stimulus involved in sensory perception of sound. Located in kinocilium and stereocilium tip. Is expressed in cochlea; inner ear; semicircular duct ampulla; tectorial membrane; and utricle epithelium. Used to study autosomal recessive nonsyndromic deafness 16. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 16 and sensorineural hearing loss. Orthologous to several human genes including STRC (stereocilin). [provided by Alliance of Genome Resources, Apr 2022]

Strc Products(1)

mRNA Protein Name
NM_080459.2 NP_536707.2 stereocilin precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within auditory receptor cell stereocilium organization IGI
IGI: Inferred from genetic interaction
30801007 MGI
acts upstream of or within auditory receptor cell stereocilium organization IMP
IMP: Inferred from mutant phenotype
18849963 MGI
involved in auditory receptor cell stereocilium organization IMP
IMP: Inferred from mutant phenotype
21165971 MGI
acts upstream of or within detection of mechanical stimulus involved in sensory perception of sound IMP
IMP: Inferred from mutant phenotype
18849963 MGI
acts upstream of or within inner ear receptor cell stereocilium organization IMP
IMP: Inferred from mutant phenotype
31776257 MGI
acts upstream of or within protein localization IMP
IMP: Inferred from mutant phenotype
31776257 MGI
Cellular Component GO Annotation Evidence Reference Source
located in kinocilium IDA
IDA: Inferred from direct assay
21165971 MGI
located in stereocilium tip IDA
IDA: Inferred from direct assay
18849963 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

stereocilin

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13963 STRC Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Strc NCBI NCBI:161497