Dmbx1 - diencephalon/mesencephalon homeobox 1 Gene

Also Known as Atx; Mbx; Cdmx; Otx3

Species: Mus musculus

Gene Type: protein coding

Gene ID: 140477

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including adult feeding behavior; adult locomotory behavior; and brain development. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; embryo ectoderm; limb bud; and sensory organ. Orthologous to human DMBX1 (diencephalon/mesencephalon homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Dmbx1 Products (2)

mRNA	Protein	Name
NM_001025567.1	NP_001020738.1	diencephalon/mesencephalon homeobox protein 1 isoform b
NM_130865.3	NP_570935.3	diencephalon/mesencephalon homeobox protein 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	12055180	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12055180	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15890343	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15890343	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	15890343	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15890343	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15890343	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within adult feeding behavior	IGI IGI: Inferred from genetic interaction	17873059	MGI
acts upstream of or within adult feeding behavior	IMP IMP: Inferred from mutant phenotype	17873059	MGI
acts upstream of or within adult locomotory behavior	IMP IMP: Inferred from mutant phenotype	17873059	MGI
involved in brain development	IEP IEP: Inferred from expression pattern	15314164	MGI
involved in central nervous system development	IEP IEP: Inferred from expression pattern	12055180	MGI
involved in developmental growth	IEP IEP: Inferred from expression pattern	15314164	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12055180	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15890343	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15890343	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of transcription regulator complex	IDA IDA: Inferred from direct assay	15890343	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
diencephalon/mesencephalon homeobox protein 1	diencephalon/mesencephalon-expressed brain homeobox gene 1 protein homeobox gene Atx orthodenticle homolog 3 paired-like homeobox protein DMBX1 paired-type homeobox Atx

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03821	DMBX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dmbx1	NCBI	NCBI:127343