2. Gene
  3. Atp6v0a4 - ATPase, H+ transporting, lysosomal V0 subunit A4 Gene

Atp6v0a4 - ATPase, H+ transporting, lysosomal V0 subunit A4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as a4; Atp6n1b

Gene ID: 140494 | Gene type: protein coding

About Atp6v0a4

Summary

Predicted to enable ATPase binding activity and P-type proton-exporting transporter activity. Acts upstream of or within proton transmembrane transport. Located in apical plasma membrane; brush border; and endosome. Part of vacuolar proton-transporting V-type ATPase complex. Is expressed in several structures, including alimentary system; genitourinary system; musculoskeletal system; respiratory system; and sensory organ. Used to study renal tubular acidosis. Human ortholog(s) of this gene implicated in renal tubular acidosis. Orthologous to human ATP6V0A4 (ATPase H+ transporting V0 subunit a4). [provided by Alliance of Genome Resources, Apr 2022]

Atp6v0a4 Products(1)

mRNA Protein Name
NM_080467.3 NP_536715.3 V-type proton ATPase 116 kDa subunit a 4
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within proton transmembrane transport IPI
IPI: Inferred from physical interaction
11498539 MGI
involved in synaptic vesicle lumen acidification EXP
EXP: Inferred from Experiment
28793259 MGI
involved in synaptic vesicle lumen acidification IDA
IDA: Inferred from direct assay
28793259 MGI
involved in synaptic vesicle lumen acidification IMP
IMP: Inferred from mutant phenotype
28793259 MGI
Cellular Component GO Annotation Evidence Reference Source
located in apical part of cell IDA
IDA: Inferred from direct assay
11495928 MGI
located in apical plasma membrane IDA
IDA: Inferred from direct assay
15385584 MGI
located in brush border IDA
IDA: Inferred from direct assay
11495928 MGI
located in endosome IDA
IDA: Inferred from direct assay
16177003 MGI
part of vacuolar proton-transporting V-type ATPase complex IPI
IPI: Inferred from physical interaction
11498539 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

V-type proton ATPase 116 kDa subunit a 4

ATPase, H+ transporting, lysosomal (vacuolar proton pump) noncatalytic accessory protein 1B

V-ATPase 116 kDa

V-ATPase 116 kDa isoform a 4

V-ATPase alpha 4

V-type proton ATPase 116 kDa subunit a

vacuolar proton translocating ATPase 100 kDa a4 subunit

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01218 ATP6V0A4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atp6v0a4 NCBI NCBI:50617