Pcyt1a - phosphate cytidylyltransferase 1A, choline Gene

Rattus norvegicus

Also known as CTP; CCT-alpha

Gene ID: 140544 | Gene type: protein coding

About Pcyt1a

Summary

Enables several functions, including Calmodulin binding activity; choline-phosphate cytidylyltransferase activity; and phosphatidylcholine binding activity. Involved in CDP-choline pathway. Located in endoplasmic reticulum; nuclear envelope; and plasma membrane. Human ortholog(s) of this gene implicated in spondylometaphyseal dysplasia with cone-rod dystrophy. Orthologous to human PCYT1A (phosphate cytidylyltransferase 1A, choline). [provided by Alliance of Genome Resources, Apr 2022]

Pcyt1a Products(1)

mRNA	Protein	Name
NM_078622.2	NP_511177.2	choline-phosphate cytidylyltransferase A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calmodulin binding	IDA IDA: Inferred from direct assay	17804406	RGD
enables choline-phosphate cytidylyltransferase activity	IDA IDA: Inferred from direct assay	2166941	RGD
enables choline-phosphate cytidylyltransferase activity	IMP IMP: Inferred from mutant phenotype	7654214	RGD
enables lipid binding	EXP EXP: Inferred from Experiment	14529288	RGD
enables lipid binding	IMP IMP: Inferred from mutant phenotype	2166941	RGD
enables molecular function inhibitor activity	IDA IDA: Inferred from direct assay	24275660	RGD
enables phosphatidylcholine binding	IDA IDA: Inferred from direct assay	9224626	RGD
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	19783652	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in CDP-choline pathway	IDA IDA: Inferred from direct assay	8185307	RGD
involved in phosphatidylcholine biosynthetic process	IDA IDA: Inferred from direct assay	8185307	RGD
involved in phosphatidylcholine biosynthetic process	IMP IMP: Inferred from mutant phenotype	12718547	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in nuclear envelope	IDA IDA: Inferred from direct assay	11583989	RGD
located in nucleus	IDA IDA: Inferred from direct assay	8185307	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

choline-phosphate cytidylyltransferase A

CCT A	CT A
CTP:phosphocholine cytidylyl transferase	CTP:phosphocholine cytidylyltransferase A
CTP:phosphocholine cytidylyltransferase alpha	choline phosphate cytidylyltransferase 1 alpha
choline-phosphate cytidylyltransferase A-like	phosphate cytid

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10180	PCYT1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pcyt1a	NCBI	NCBI:5130

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