AP2B1 - Ap2b1 adaptor related protein complex 2 subunit beta 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 140670

Summary

Enables clathrin binding activity. Involved in several processes, including clathrin coat assembly; negative regulation of neuron death; and positive regulation of endocytosis. Part of clathrin coat. Biomarker of middle cerebral artery infarction. Orthologous to human AP2B1 (adaptor related protein complex 2 subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]

AP2B1 Products (1)

mRNA Protein Name
NM_080583.2 NP_542150.1 AP-2 complex subunit beta

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables clathrin binding IDA
IDA: Inferred from direct assay
8262066 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10428863 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
12297494 RGD
Biological Process GO Annotation Evidence References Source
involved in clathrin coat assembly IDA
IDA: Inferred from direct assay
8262066 RGD
involved in positive regulation of endocytosis IMP
IMP: Inferred from mutant phenotype
19240038 RGD
involved in positive regulation of protein localization to membrane IMP
IMP: Inferred from mutant phenotype
19240038 RGD
involved in postsynaptic neurotransmitter receptor internalization EXP
EXP: Inferred from Experiment
17289840 RGD
involved in postsynaptic neurotransmitter receptor internalization IDA
IDA: Inferred from direct assay
17289840 RGD
involved in postsynaptic neurotransmitter receptor internalization IMP
IMP: Inferred from mutant phenotype
17289840 RGD
Cellular Component GO Annotation Evidence References Source
part of clathrin coat IDA
IDA: Inferred from direct assay
8262066 RGD
is active in extrinsic component of presynaptic endocytic zone membrane IDA
IDA: Inferred from direct assay
8682861 RGD
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
17289840 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
17289840 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
17289840 RGD
is active in postsynaptic endocytic zone IDA
IDA: Inferred from direct assay
35072626 RGD
is active in postsynaptic endocytic zone IMP
IMP: Inferred from mutant phenotype
35072626 RGD
is active in synaptic vesicle EXP
EXP: Inferred from Experiment
33376223 RGD
is active in synaptic vesicle IDA
IDA: Inferred from direct assay
33376223 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

AP-2 complex subunit beta

  • AP-1 complex subunit beta-1-like

  • AP-2 complex subunit beta-like

  • AP105B

  • adapter-related protein complex 2 beta subunit

  • adapter-related protein complex 2 subunit beta

  • adaptor protein complex AP-2 subunit beta

  • adaptor-related protein complex 2 subunit

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00786 AP2B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens AP2B1 NCBI NCBI:163