AP2B1 - Ap2b1 adaptor related protein complex 2 subunit beta 1 Gene

Rattus norvegicus

Gene ID: 140670 | Gene type: protein coding

About AP2B1

Summary

Enables clathrin binding activity. Involved in several processes, including clathrin coat assembly; negative regulation of neuron death; and positive regulation of endocytosis. Part of clathrin coat. Biomarker of middle cerebral artery infarction. Orthologous to human AP2B1 (adaptor related protein complex 2 subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]

AP2B1 Products(1)

mRNA	Protein	Name
NM_080583.2	NP_542150.1	AP-2 complex subunit beta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables clathrin binding	IDA IDA: Inferred from direct assay	8262066	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10428863	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	12297494	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in clathrin coat assembly	IDA IDA: Inferred from direct assay	8262066	RGD
involved in positive regulation of endocytosis	IMP IMP: Inferred from mutant phenotype	19240038	RGD
involved in positive regulation of protein localization to membrane	IMP IMP: Inferred from mutant phenotype	19240038	RGD
involved in postsynaptic neurotransmitter receptor internalization	EXP EXP: Inferred from Experiment	17289840	RGD
involved in postsynaptic neurotransmitter receptor internalization	IDA IDA: Inferred from direct assay	17289840	RGD
involved in postsynaptic neurotransmitter receptor internalization	IMP IMP: Inferred from mutant phenotype	17289840	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of clathrin coat	IDA IDA: Inferred from direct assay	8262066	RGD
is active in extrinsic component of presynaptic endocytic zone membrane	IDA IDA: Inferred from direct assay	8682861	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	17289840	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	17289840	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	17289840	RGD
is active in postsynaptic endocytic zone	IDA IDA: Inferred from direct assay	35072626	RGD
is active in postsynaptic endocytic zone	IMP IMP: Inferred from mutant phenotype	35072626	RGD
is active in synaptic vesicle	EXP EXP: Inferred from Experiment	33376223	RGD
is active in synaptic vesicle	IDA IDA: Inferred from direct assay	33376223	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

AP-2 complex subunit beta

AP-1 complex subunit beta-1-like	AP-2 complex subunit beta-like
AP105B	adapter-related protein complex 2 beta subunit
adapter-related protein complex 2 subunit beta	adaptor protein complex AP-2 subunit beta
adaptor-related protein complex 2 subunit

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00786	AP2B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	AP2B1	NCBI	NCBI:163

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