2. Gene
  3. Sesn1 - sestrin 1 Gene

Sesn1 - sestrin 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Pa26; Sest1; 1110002G11Rik

Gene ID: 140742 | Gene type: protein coding

About Sesn1

Summary

Predicted to enable leucine binding activity and oxidoreductase activity, acting on peroxide as acceptor. Involved in cellular response to amino acid stimulus; negative regulation of TORC1 signaling; and negative regulation of cell growth. Acts upstream of or within regulation of protein kinase B signaling. Predicted to be located in cytoplasm; fibrillar center; and nucleoplasm. Predicted to be part of GATOR2 complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human SESN1 (sestrin 1). [provided by Alliance of Genome Resources, Apr 2022]

Sesn1 Products(2)

mRNA Protein Name
NM_001013370.2 NP_001013388.2 sestrin-1 isoform 2
NM_001162908.1 NP_001156380.1 sestrin-1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25259925 MGI
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to amino acid stimulus IMP
IMP: Inferred from mutant phenotype
25259925 MGI
involved in negative regulation of TORC1 signaling IMP
IMP: Inferred from mutant phenotype
25259925 MGI
involved in negative regulation of cell growth IDA
IDA: Inferred from direct assay
20203043 MGI
acts upstream of or within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
22958918 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sestrin-1

p53 regulated Pa26 nuclear protein

p53-regulated protein PA26

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12734 SESN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sesn1 NCBI NCBI:27244