Fcgr1 - Fc receptor, IgG, high affinity I Gene

Also Known as CD64; IGGHAFC; FcgammaRI

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14129

Summary

Enables IgG binding activity and IgG receptor activity. Acts upstream of or within several processes, including antibody-dependent cellular cytotoxicity; endocytosis; and positive regulation of hypersensitivity. Located in external side of plasma membrane. Is expressed in liver. Orthologous to several human genes including FCGR1A (Fc gamma receptor Ia). [provided by Alliance of Genome Resources, Apr 2022]

Fcgr1 Products (1)

mRNA Protein Name
NM_010186.5 NP_034316.1 high affinity immunoglobulin gamma Fc receptor I precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables IgG binding IDA
IDA: Inferred from direct assay
9551950 MGI
enables IgG binding IMP
IMP: Inferred from mutant phenotype
11911823 MGI
enables IgG receptor activity IMP
IMP: Inferred from mutant phenotype
9551950 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within antibody-dependent cellular cytotoxicity IMP
IMP: Inferred from mutant phenotype
11911823 MGI
acts upstream of or within antigen processing and presentation of exogenous antigen IMP
IMP: Inferred from mutant phenotype
11911823 MGI
acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class I IMP
IMP: Inferred from mutant phenotype
11911824 MGI
acts upstream of or within cell surface receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
9551950 MGI
acts upstream of or within defense response to bacterium IMP
IMP: Inferred from mutant phenotype
11911824 MGI
acts upstream of or within phagocytosis, engulfment IMP
IMP: Inferred from mutant phenotype
9551950 MGI
acts upstream of or within phagocytosis, recognition IMP
IMP: Inferred from mutant phenotype
9551950 MGI
acts upstream of or within positive regulation of phagocytosis IMP
IMP: Inferred from mutant phenotype
9551950 MGI
acts upstream of or within positive regulation of type III hypersensitivity IMP
IMP: Inferred from mutant phenotype
11911823 MGI
acts upstream of or within positive regulation of type IIa hypersensitivity IMP
IMP: Inferred from mutant phenotype
11911824 MGI
acts upstream of or within receptor-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
11911823 MGI
acts upstream of or within regulation of immune response IMP
IMP: Inferred from mutant phenotype
11911823 MGI
acts upstream of or within response to bacterium IMP
IMP: Inferred from mutant phenotype
16836651 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
11911823 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

high affinity immunoglobulin gamma Fc receptor I

  • IgG high affinity Fc receptor

  • fc-gamma RI

  • fcRI

  • igG Fc receptor I

Recombinant Fcgr1 Proteins

Cat. No. Product Name Accession Purity
HY-P72714 CD64 Protein, Mouse (HEK293, His) P26151 (E25-P297) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72927 CD64 Protein, Mouse (HEK293, His-Avi) P26151 (E25-P297) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04827 FCGR1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24478 Fcgr1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown