Flot1 - flotillin 1 Gene

Also Known as reggie-2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 14251

Summary

Predicted to enable ionotropic glutamate receptor binding activity and protease binding activity. Involved in several processes, including positive regulation of cell-cell adhesion mediated by cadherin; positive regulation of cellular component organization; and positive regulation of dopaminergic synaptic transmission. Acts upstream of or within axonogenesis; protein localization to plasma membrane; and regulation of Rho protein signal transduction. Located in caveola; external side of plasma membrane; and sarcolemma. Part of flotillin complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human FLOT1 (flotillin 1). [provided by Alliance of Genome Resources, Apr 2022]

Flot1 Products (13)

mRNA	Protein	Name
NM_001410113.1	NP_001397042.1	flotillin-1 isoform 1
NM_001410114.1	NP_001397043.1	flotillin-1 isoform 1
NM_001410115.1	NP_001397044.1	flotillin-1 isoform 1
NM_001410116.1	NP_001397045.1	flotillin-1 isoform 1
NM_001410117.1	NP_001397046.1	flotillin-1 isoform 2
NM_001410118.1	NP_001397047.1	flotillin-1 isoform 5
NM_001410119.1	NP_001397048.1	flotillin-1 isoform 3
NM_001410121.1	NP_001397050.1	flotillin-1 isoform 7
NM_001410122.1	NP_001397051.1	flotillin-1 isoform 8
NM_001410125.1	NP_001397054.1	flotillin-1 isoform 6
NM_001410126.1	NP_001397055.1	flotillin-1 isoform 6
NM_001410127.1	NP_001397056.1	flotillin-1 isoform 4
NM_008027.3	NP_032053.1	flotillin-1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11001060	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within axonogenesis	IMP IMP: Inferred from mutant phenotype	19458231	MGI
involved in intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	21399631	MGI
involved in positive regulation of cell junction assembly	IMP IMP: Inferred from mutant phenotype	24046456	MGI
involved in positive regulation of cell-cell adhesion mediated by cadherin	IMP IMP: Inferred from mutant phenotype	24046456	MGI
involved in positive regulation of endocytosis	IMP IMP: Inferred from mutant phenotype	21399631	MGI
involved in positive regulation of myoblast fusion	IMP IMP: Inferred from mutant phenotype	24046456	MGI
involved in positive regulation of protein binding	IMP IMP: Inferred from mutant phenotype	24046456	MGI
involved in positive regulation of skeletal muscle tissue development	IMP IMP: Inferred from mutant phenotype	24046456	MGI
involved in positive regulation of synaptic transmission, dopaminergic	IMP IMP: Inferred from mutant phenotype	21399631	MGI
acts upstream of or within protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	16455755	MGI
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	24046456	MGI
acts upstream of or within regulation of Rho protein signal transduction	IMP IMP: Inferred from mutant phenotype	19458231	MGI
involved in regulation of receptor internalization	IMP IMP: Inferred from mutant phenotype	21399631	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in caveola	IDA IDA: Inferred from direct assay	9153235	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	25429154	MGI
part of flotillin complex	IDA IDA: Inferred from direct assay	11001060	MGI
located in membrane	IDA IDA: Inferred from direct assay	16455755	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	12388596	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	12370178	MGI
located in plasma membrane raft	IDA IDA: Inferred from direct assay	24046456	MGI
located in sarcolemma	IDA IDA: Inferred from direct assay	16455755	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
flotillin-1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04982	FLOT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Flot1	NCBI	NCBI:10211