Fmn1 - formin 1 Gene

Also Known as ld; Fmn; formin-1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 14260

Summary

Enables SH3 domain binding activity and microtubule binding activity. Acts upstream of or within several processes, including animal organ morphogenesis; limb morphogenesis; and positive regulation of cellular component organization. Located in cytoplasm; microtubule cytoskeleton; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb bud; and spleen. Orthologous to human FMN1 (formin 1). [provided by Alliance of Genome Resources, Apr 2022]

Fmn1 Products (5)

mRNA	Protein	Name
NM_001285458.1	NP_001272387.1	formin-1 isoform 3
NM_001285459.1	NP_001272388.1	formin-1 isoform 4
NM_001287817.1	NP_001274746.1	formin-1 isoform 5
NM_001287818.1	NP_001274747.1	formin-1 isoform 5
NM_010230.2	NP_034360.2	formin-1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SH3 domain binding	IPI IPI: Inferred from physical interaction	8438166	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8605874	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within forelimb morphogenesis	IMP IMP: Inferred from mutant phenotype	17554679	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	17554679	MGI
acts upstream of or within hindlimb morphogenesis	IMP IMP: Inferred from mutant phenotype	17554679	MGI
acts upstream of or within limb development	IMP IMP: Inferred from mutant phenotype	2997621	MGI
acts upstream of or within positive regulation of actin filament polymerization	IDA IDA: Inferred from direct assay	14647292	MGI
acts upstream of or within positive regulation of actin nucleation	IDA IDA: Inferred from direct assay	14647292	MGI
acts upstream of or within positive regulation of focal adhesion assembly	IMP IMP: Inferred from mutant phenotype	18560567	MGI
acts upstream of or within skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	17554679	MGI
acts upstream of or within ureteric bud invasion	IMP IMP: Inferred from mutant phenotype	7517224	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	8798555	MGI
located in nucleus	IDA IDA: Inferred from direct assay	8798555	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
formin-1	limb deformity protein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05000	FMN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W141871	DL-Thyronine		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fmn1	NCBI	NCBI:342184