2. Gene
  3. Aff2 - AF4/FMR2 family, member 2 Gene

Aff2 - AF4/FMR2 family, member 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Oxh; Fmr2; Ox19; FMR2P

Gene ID: 14266 | Gene type: protein coding

About Aff2

Summary

Enables G-quadruplex RNA binding activity. Involved in regulation of RNA splicing. Acts upstream of or within learning or memory and negative regulation of gene expression. Located in nuclear speck. Is expressed in several structures, including branchial arch; heart; limb; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in X-linked intellectual developmental disorder 109. Orthologous to human AFF2 (AF4/FMR2 family member 2). [provided by Alliance of Genome Resources, Apr 2022]

Aff2 Products(1)

mRNA Protein Name
NM_008032.3 NP_032058.2 AF4/FMR2 family member 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables G-quadruplex RNA binding IDA
IDA: Inferred from direct assay
19136466 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within learning or memory IMP
IMP: Inferred from mutant phenotype
11923441 MGI
acts upstream of or within negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
23562910 MGI
involved in regulation of RNA splicing IDA
IDA: Inferred from direct assay
19136466 MGI
Cellular Component GO Annotation Evidence Reference Source
located in nuclear speck IDA
IDA: Inferred from direct assay
19136466 MGI
located in nucleus IDA
IDA: Inferred from direct assay
26013685 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

AF4/FMR2 family member 2

Ox19 homolog

protein FMR-2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00429 AFF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aff2 NCBI NCBI:2334