Fut1 - fucosyltransferase 1 Gene

Also Known as MFUT-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14343

Summary

This gene is one of three genes in mouse which encode a galactoside 2-L-fucosyltransferase. These genes differ in their developmental- and tissue-specific expression. The encoded type II membrane protein is anchored in the Golgi apparatus and controls the final step in the creation of alpha (1,2) fucosylated carbhohydrates by the addition of a terminal fucose in an alpha (1,2) linkage. This enzyme is required for the synthesis of the Lewis antigen as well as the H-antigen, a precursor of the A and B antigens of the ABH histo-blood group. The biological function of the fucosylated carbhohydrate products is thought to involve cell-adhesion and interactions with Microorganisms. Disruption of this gene impairs development of the olfactory nerve and maturation of the glomerular layer of the main olfactory bulb. Alternative splicing results in multiple transcript variants which encode distinct isoforms. [provided by RefSeq, Dec 2012]

Fut1 Products (2)

mRNA Protein Name
NM_001271981.1 NP_001258910.1 galactoside alpha-(1,2)-fucosyltransferase 1 isoform 2
NM_008051.6 NP_032077.2 galactoside alpha-(1,2)-fucosyltransferase 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables alpha-(1,2)-fucosyltransferase activity IDA
IDA: Inferred from direct assay
11368156 MGI
enables fucosyltransferase activity IMP
IMP: Inferred from mutant phenotype
11713270 MGI
enables galactoside 2-alpha-L-fucosyltransferase activity IDA
IDA: Inferred from direct assay
9355741 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within fucosylation IDA
IDA: Inferred from direct assay
9355741 MGI
involved in fucosylation IDA
IDA: Inferred from direct assay
14967068 MGI
involved in olfactory bulb development IMP
IMP: Inferred from mutant phenotype
16884711 MGI
involved in oligosaccharide biosynthetic process IMP
IMP: Inferred from mutant phenotype
11713270 MGI
involved in protein glycosylation IDA
IDA: Inferred from direct assay
11368156 MGI
involved in regulation of cell adhesion IDA
IDA: Inferred from direct assay
20506485 MGI
involved in regulation of endothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
20506485 MGI
Cellular Component GO Annotation Evidence References Source
is active in Golgi apparatus IMP
IMP: Inferred from mutant phenotype
11713270 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

galactoside alpha-(1,2)-fucosyltransferase 1

  • GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1

  • H transferase

  • alpha(1,2)FT 1

  • beta-galactoside alpha-1,2-fucosyltransferase

  • galactoside 2-alpha-L-fucosyltransferase 1

  • type 1 galactoside alpha-(1,2)-fucosyltransferase FUT1

  • type 2 galact

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05150 FUT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19602 Fut1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26098 Fut1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fut1 NCBI NCBI:2523