Fzd6 - frizzled class receptor 6 Gene

Also Known as Fz6

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14368

Summary

Enables Wnt-protein binding activity. Acts upstream of or within several processes, including cell proliferation in midbrain; embryonic morphogenesis; and establishment of body hair planar orientation. Located in apical plasma membrane; apicolateral plasma membrane; and endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in nonsyndromic congenital nail disorder 1. Orthologous to human FZD6 (Frizzled class receptor 6). [provided by Alliance of Genome Resources, Apr 2022]

Fzd6 Products (4)

mRNA Protein Name
NM_001162494.1 NP_001155966.1 frizzled-6 isoform 1 precursor
NM_001411226.1 NP_001398155.1 frizzled-6 isoform 1 precursor
NM_001411227.1 NP_001398156.1 frizzled-6 isoform 2 precursor
NM_008056.4 NP_032082.3 frizzled-6 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Wnt-protein binding IPI
IPI: Inferred from physical interaction
15265686 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18606138 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway IDA
IDA: Inferred from direct assay
18606138 MGI
acts upstream of or within cell proliferation in midbrain IGI
IGI: Inferred from genetic interaction
19842188 MGI
acts upstream of or within embryonic nail plate morphogenesis IMP
IMP: Inferred from mutant phenotype
23439395 MGI
acts upstream of or within establishment of body hair planar orientation IGI
IGI: Inferred from genetic interaction
26418459 MGI
acts upstream of or within establishment of planar polarity IGI
IGI: Inferred from genetic interaction
16495441 MGI
acts upstream of or within hair follicle development IMP
IMP: Inferred from mutant phenotype
15169958 MGI
acts upstream of or within inner ear morphogenesis IGI
IGI: Inferred from genetic interaction
16495441 MGI
acts upstream of or within midbrain development IGI
IGI: Inferred from genetic interaction
19842188 MGI
acts upstream of or within neural tube closure IGI
IGI: Inferred from genetic interaction
16495441 MGI
acts upstream of or within platelet activation IMP
IMP: Inferred from mutant phenotype
19901330 MGI
Cellular Component GO Annotation Evidence References Source
located in apical part of cell IDA
IDA: Inferred from direct assay
16495441 MGI
located in apical plasma membrane IDA
IDA: Inferred from direct assay
25393619 MGI
located in apicolateral plasma membrane IDA
IDA: Inferred from direct assay
17376975 MGI
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
31073040 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
31073040 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

frizzled-6

  • frizzled homolog 6

  • fz-6

  • mFz6

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05182 FZD6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19132 Fzd6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25622 Fzd6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fzd6 NCBI NCBI:8323