G6pdx - glucose-6-phosphate dehydrogenase X-linked Gene

Also Known as G28A; G6pd; Gpdx

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14381

Summary

Enables glucose-6-phosphate dehydrogenase activity and identical protein binding activity. Acts upstream of or within several processes, including NADP biosynthetic process; erythrocyte development; and maintenance of blood vessel diameter homeostasis by renin-angiotensin. Predicted to be located in several cellular components, including centriolar satellite; cytoplasmic side of plasma membrane; and cytosol. Is expressed in several structures, including adipose tissue; genitourinary system; immune system; liver; and mammary gland. Used to study favism. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cerebrovascular disease; favism; malaria (multiple); and neonatal jaundice. Orthologous to human G6PD (glucose-6-phosphate dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]

G6pdx Products (1)

mRNA Protein Name
NM_008062.3 NP_032088.1 glucose-6-phosphate 1-dehydrogenase X

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glucose-6-phosphate dehydrogenase activity IDA
IDA: Inferred from direct assay
943046 MGI
enables glucose-6-phosphate dehydrogenase activity IMP
IMP: Inferred from mutant phenotype
1953691 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
9169132 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within NADP biosynthetic process IDA
IDA: Inferred from direct assay
7439685 MGI
acts upstream of or within NADP biosynthetic process IMP
IMP: Inferred from mutant phenotype
1953691 MGI
acts upstream of or within angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure IMP
IMP: Inferred from mutant phenotype
15998684 MGI
acts upstream of or within angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure IMP
IMP: Inferred from mutant phenotype
15998684 MGI
acts upstream of or within cytokine production IMP
IMP: Inferred from mutant phenotype
15817708 MGI
acts upstream of or within erythrocyte development IMP
IMP: Inferred from mutant phenotype
14751857 MGI
acts upstream of or within glutathione metabolic process IMP
IMP: Inferred from mutant phenotype
12521604 MGI
acts upstream of or within interleukin-10 production IMP
IMP: Inferred from mutant phenotype
15817708 MGI
acts upstream of or within interleukin-12 production IMP
IMP: Inferred from mutant phenotype
15817708 MGI
acts upstream of or within pentose biosynthetic process IDA
IDA: Inferred from direct assay
7439685 MGI
acts upstream of or within pentose biosynthetic process IMP
IMP: Inferred from mutant phenotype
1953691 MGI
involved in pentose-phosphate shunt, oxidative branch IMP
IMP: Inferred from mutant phenotype
12466018 MGI
acts upstream of or within regulation of multicellular organism growth IMP
IMP: Inferred from mutant phenotype
10627286 MGI
acts upstream of or within response to oxidative stress IMP
IMP: Inferred from mutant phenotype
7489710 MGI
Cellular Component GO Annotation Evidence References Source
is active in cytosol IDA
IDA: Inferred from direct assay
12466018 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glucose-6-phosphate 1-dehydrogenase X

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS22997 G6pd Rat Pre-designed siRNA Set A Pre-designed Set / Unkown