Slc37a4 - solute carrier family 37 (glucose-6-phosphate transporter), member 4 Gene

Also Known as G6PT; G6pt1; mG6PT; GSD-1b; 100043178

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14385

Summary

Predicted to enable glucose 6-phosphate:inorganic phosphate antiporter activity and glucose-6-phosphate transmembrane transporter activity. Acts upstream of or within several processes, including Cholesterol homeostasis; glucose-6-phosphate transport; and hemopoiesis. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be integral component of endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; genitourinary system; liver; nervous system; and spleen. Used to study glycogen storage disease I. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to human SLC37A4 (solute carrier family 37 member 4). [provided by Alliance of Genome Resources, Apr 2022]

Slc37a4 Products (12)

mRNA Protein Name
NM_001293630.2 NP_001280559.1 glucose-6-phosphate exchanger SLC37A4 isoform b
NM_001293631.2 NP_001280560.1 glucose-6-phosphate exchanger SLC37A4 isoform b
NM_001357729.2 NP_001344658.1 glucose-6-phosphate exchanger SLC37A4 isoform a
NM_001357730.2 NP_001344659.1 glucose-6-phosphate exchanger SLC37A4 isoform a
NM_001378829.1 NP_001365758.1 glucose-6-phosphate exchanger SLC37A4 isoform a
NM_001378830.1 NP_001365759.1 glucose-6-phosphate exchanger SLC37A4 isoform b
NM_001378831.1 NP_001365760.1 glucose-6-phosphate exchanger SLC37A4 isoform c precursor
NM_001378832.1 NP_001365761.1 glucose-6-phosphate exchanger SLC37A4 isoform c precursor
NM_001378833.1 NP_001365762.1 glucose-6-phosphate exchanger SLC37A4 isoform c precursor
NM_001378834.1 NP_001365763.1 glucose-6-phosphate exchanger SLC37A4 isoform d precursor
NM_001411170.1 NP_001398099.1 glucose-6-phosphate exchanger SLC37A4 isoform d precursor
NM_008063.3 NP_032089.2 glucose-6-phosphate exchanger SLC37A4 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glucose 6-phosphate:phosphate antiporter activity IGI
IGI: Inferred from genetic interaction
17006547 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of chemokine production IMP
IMP: Inferred from mutant phenotype
16891306 MGI
acts upstream of or within cholesterol homeostasis IMP
IMP: Inferred from mutant phenotype
16891306 MGI
acts upstream of or within cytokine production IMP
IMP: Inferred from mutant phenotype
12925567 MGI
involved in gluconeogenesis IDA
IDA: Inferred from direct assay
28973635 MGI
acts upstream of or within glucose homeostasis IMP
IMP: Inferred from mutant phenotype
12925567 MGI
acts upstream of or within glucose-6-phosphate transport IDA
IDA: Inferred from direct assay
11121425 MGI
acts upstream of or within glucose-6-phosphate transport IGI
IGI: Inferred from genetic interaction
15661744 MGI
acts upstream of or within glucose-6-phosphate transport IMP
IMP: Inferred from mutant phenotype
15661744 MGI
acts upstream of or within glycogen metabolic process IMP
IMP: Inferred from mutant phenotype
12925567 MGI
acts upstream of or within intracellular calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
12925567 MGI
acts upstream of or within lactate metabolic process IMP
IMP: Inferred from mutant phenotype
16891306 MGI
acts upstream of or within myeloid progenitor cell differentiation IMP
IMP: Inferred from mutant phenotype
16891306 MGI
acts upstream of or within negative regulation of chemokine production IMP
IMP: Inferred from mutant phenotype
16891306 MGI
acts upstream of or within neutrophil chemotaxis IMP
IMP: Inferred from mutant phenotype
16891306 MGI
acts upstream of or within neutrophil homeostasis IMP
IMP: Inferred from mutant phenotype
16891306 MGI
acts upstream of or within positive regulation of catalytic activity IMP
IMP: Inferred from mutant phenotype
17588937 MGI
acts upstream of or within post-embryonic hemopoiesis IMP
IMP: Inferred from mutant phenotype
12925567 MGI
acts upstream of or within respiratory burst IMP
IMP: Inferred from mutant phenotype
16891306 MGI
acts upstream of or within steroid metabolic process IMP
IMP: Inferred from mutant phenotype
17588937 MGI
acts upstream of or within triglyceride metabolic process IMP
IMP: Inferred from mutant phenotype
12925567 MGI
Cellular Component GO Annotation Evidence References Source
is active in endoplasmic reticulum membrane IGI
IGI: Inferred from genetic interaction
17006547 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glucose-6-phosphate exchanger SLC37A4

  • glucose 6-phosphate transporter

  • glucose-6-phosphatase, transport protein 1

  • solute carrier family 37 (glycerol-6-phosphate transporter), member 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13216 SLC37A4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21257 Slc37a4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27776 Slc37a4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc37a4 NCBI NCBI:2542