Gabra1 - gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1 Gene

Also Known as Gabra-1; GABAA-alpha1; GABAAR-alpha1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14394

Summary

Enables transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Contributes to GABA-gated chloride ion channel activity. Involved in inhibitory synapse assembly and regulation of postsynaptic membrane potential. Located in GABA-ergic synapse and plasma membrane. Is expressed in alimentary system; central nervous system; and eye. Used to study idiopathic generalized epilepsy. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 19 and idiopathic generalized epilepsy 13. Orthologous to human GABRA1 (gamma-aminobutyric acid type A receptor subunit alpha1). [provided by Alliance of Genome Resources, Apr 2022]

Gabra1 Products (2)

mRNA Protein Name
NM_001359035.1 NP_001345964.1 gamma-aminobutyric acid receptor subunit alpha-1 precursor
NM_010250.5 NP_034380.1 gamma-aminobutyric acid receptor subunit alpha-1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to GABA-gated chloride ion channel activity IDA
IDA: Inferred from direct assay
27129275 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12574411 MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential EXP
EXP: Inferred from Experiment
12466441 MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
IDA: Inferred from direct assay
12466441 MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
12466441 MGI
Biological Process GO Annotation Evidence References Source
involved in inhibitory synapse assembly IDA
IDA: Inferred from direct assay
27129275 MGI
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse EXP
EXP: Inferred from Experiment
12466441 MGI
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
12466441 MGI
is active in GABA-ergic synapse IMP
IMP: Inferred from mutant phenotype
12466441 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
25579817 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gamma-aminobutyric acid receptor subunit alpha-1

  • GABA(A) receptor subunit alpha-1

  • GABAA alpha 1

  • GABAAR alpha1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05209 GABRA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gabra1 NCBI NCBI:2554