Gabra3 - gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3 Gene

Also Known as Gabra-3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14396

Summary

Enables transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in several processes, including GABAergic synaptic transmission; chloride transmembrane transport; and gamma-aminobutyric acid signaling pathway. Predicted to act upstream of or within ion transport. Located in GABA-ergic synapse. Is integral component of postsynaptic specialization membrane. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and immune system. Human ortholog(s) of this gene implicated in bipolar disorder and multiple sclerosis. Orthologous to human GABRA3 (gamma-aminobutyric acid type A receptor subunit alpha3). [provided by Alliance of Genome Resources, Apr 2022]

Gabra3 Products (5)

mRNA Protein Name
NM_001357814.1 NP_001344743.1 gamma-aminobutyric acid receptor subunit alpha-3 isoform 1 precursor
NM_001357815.1 NP_001344744.1 gamma-aminobutyric acid receptor subunit alpha-3 isoform 2
NM_001357816.1 NP_001344745.1 gamma-aminobutyric acid receptor subunit alpha-3 isoform 3
NM_001358103.1 NP_001345032.1 gamma-aminobutyric acid receptor subunit alpha-3 isoform 1 precursor
NM_008067.4 NP_032093.3 gamma-aminobutyric acid receptor subunit alpha-3 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential EXP
EXP: Inferred from Experiment
22666188 MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
IDA: Inferred from direct assay
22666188 MGI
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse EXP
EXP: Inferred from Experiment
22666188 MGI
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
22666188 MGI
is active in postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
22666188 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gamma-aminobutyric acid receptor subunit alpha-3

  • GABA(A) receptor subunit alpha-3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05211 GABRA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gabra3 NCBI NCBI:2556