Gabrb2 - gamma-aminobutyric acid (GABA) A receptor, subunit beta 2 Gene

Also Known as Gabrab2; Gabrb-2; C030002O17Rik; C030021G16Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14401

Summary

Enables transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Contributes to GABA-gated chloride ion channel activity. Involved in several processes, including inner ear development; nervous system development; and sensory perception of sound. Located in plasma membrane. Is active in GABA-ergic synapse. Is integral component of postsynaptic specialization membrane. Is expressed in several structures, including alimentary system; heart; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autistic disorder and developmental and epileptic encephalopathy 92. Orthologous to human GABRB2 (gamma-aminobutyric acid type A receptor subunit beta2). [provided by Alliance of Genome Resources, Apr 2022]

Gabrb2 Products (5)

mRNA Protein Name
NM_001347314.3 NP_001334243.1 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor
NM_001362646.2 NP_001349575.1 gamma-aminobutyric acid receptor subunit beta-2 isoform 2 precursor
NM_001362647.2 NP_001349576.1 gamma-aminobutyric acid receptor subunit beta-2 isoform 2 precursor
NM_001362649.2 NP_001349578.1 gamma-aminobutyric acid receptor subunit beta-2 isoform 3
NM_008070.5 NP_032096.1 gamma-aminobutyric acid receptor subunit beta-2 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to GABA-gated chloride ion channel activity IDA
IDA: Inferred from direct assay
27129275 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12574411 MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
IDA: Inferred from direct assay
26179122 MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
26179122 MGI
Biological Process GO Annotation Evidence References Source
involved in cochlea development IMP
IMP: Inferred from mutant phenotype
17021187 MGI
involved in inhibitory synapse assembly IDA
IDA: Inferred from direct assay
27129275 MGI
involved in inner ear receptor cell development IMP
IMP: Inferred from mutant phenotype
17021187 MGI
involved in innervation IMP
IMP: Inferred from mutant phenotype
17021187 MGI
involved in neuron development IMP
IMP: Inferred from mutant phenotype
17021187 MGI
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
26179122 MGI
is active in GABA-ergic synapse IMP
IMP: Inferred from mutant phenotype
26179122 MGI
is active in postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
26297893 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gamma-aminobutyric acid receptor subunit beta-2

  • GABA(A) receptor subunit beta-2

  • gamma-aminobutyric acid A receptor, subunit beta 2

  • gamma-aminobutyric acid receptor beta-2 subunit

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05216 GABRB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21133 Gabrb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27651 Gabrb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gabrb2 NCBI NCBI:2561