Gabrd - gamma-aminobutyric acid (GABA) A receptor, subunit delta Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14403

Summary

Enables transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in several processes, including chemical synaptic transmission; chloride transmembrane transport; and regulation of membrane potential. Predicted to act upstream of or within chloride transport. Located in axon; dendrite; and neuronal cell body. Is integral component of postsynaptic membrane. Is active in GABA-ergic synapse. Is expressed in several structures, including brain; metanephros; respiratory system; sensory organ; and ventricular layer. Used to study postpartum depression. Human ortholog(s) of this gene implicated in idiopathic generalized epilepsy 10. Orthologous to human GABRD (gamma-aminobutyric acid type A receptor subunit delta). [provided by Alliance of Genome Resources, Apr 2022]

Gabrd Products (1)

mRNA Protein Name
NM_008072.2 NP_032098.2 gamma-aminobutyric acid receptor subunit delta precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
IDA: Inferred from direct assay
14627650 MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
14627650 MGI
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
14627650 MGI
is active in GABA-ergic synapse IMP
IMP: Inferred from mutant phenotype
14627650 MGI
located in axon IDA
IDA: Inferred from direct assay
25339733 MGI
located in dendrite IDA
IDA: Inferred from direct assay
25339733 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
25339733 MGI
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
14627650 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gamma-aminobutyric acid receptor subunit delta

  • GABA(A) receptor subunit delta

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05218 GABRD Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gabrd NCBI NCBI:2563