Gabrg2 - gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Gene

Mus musculus

Also known as gamma2; GABAA-R; Gabrg-2

Gene ID: 14406 | Gene type: protein coding

About Gabrg2

Summary

This gene encodes a gamma-aminobutyric acid (GABA)-A receptor subunit, which is a member of the ligand-gated ion channel family. GABA is the major inhibitory neurotransmitter in the adult central nervous system, and conversely exhibits an excitatory function during development. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. This gene encodes one of three gamma subunits in mammals, which contain the binding site for benzodiazepine drugs. Several mutations in this gene are associated with epileptic seizures, and genetic knockdown is associated with anxiety behavior. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Gabrg2 Products(4)

mRNA	Protein	Name
NM_001362655.1	NP_001349584.1	gamma-aminobutyric acid receptor subunit gamma-2 isoform 3 precursor
NM_001362656.1	NP_001349585.1	gamma-aminobutyric acid receptor subunit gamma-2 isoform 4 precursor
NM_008073.4	NP_032099.1	gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor
NM_177408.7	NP_803127.3	gamma-aminobutyric acid receptor subunit gamma-2 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GABA-A receptor activity	IDA IDA: Inferred from direct assay	12574411	MGI
enables GABA-A receptor activity	IMP IMP: Inferred from mutant phenotype	18281286	MGI
contributes to GABA-gated chloride ion channel activity	IDA IDA: Inferred from direct assay	27129275	MGI
enables chloride channel activity	IMP IMP: Inferred from mutant phenotype	18281286	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12574411	MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA IDA: Inferred from direct assay	15659595	MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	15659595	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within adult behavior	IMP IMP: Inferred from mutant phenotype	15850489	MGI
involved in cellular response to histamine	IDA IDA: Inferred from direct assay	18281286	MGI
acts upstream of or within chemical synaptic transmission	IDA IDA: Inferred from direct assay	12574411	MGI
involved in chloride transmembrane transport	IMP IMP: Inferred from mutant phenotype	18281286	MGI
acts upstream of or within gamma-aminobutyric acid signaling pathway	IDA IDA: Inferred from direct assay	12574411	MGI
involved in inhibitory synapse assembly	IDA IDA: Inferred from direct assay	27129275	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	15850489	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of GABA-A receptor complex	IMP IMP: Inferred from mutant phenotype	18281286	MGI
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	15659595	MGI
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	15659595	MGI
located in axon	IDA IDA: Inferred from direct assay	9682826	MGI
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	18281286	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

gamma-aminobutyric acid receptor subunit gamma-2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05221	GABRG2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gabrg2	NCBI	NCBI:2566

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