2. Gene
  3. Slc6a12 - solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 Gene

Slc6a12 - solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as BGT1; GAT2; GAT-2; Gabt2

Gene ID: 14411 | Gene type: protein coding

About Slc6a12

Summary

Predicted to enable gamma-aminobutyric acid:sodium symporter activity. Predicted to be involved in cellular water homeostasis; monocarboxylic acid transport; and sodium ion transmembrane transport. Predicted to act upstream of or within neurotransmitter transport. Predicted to be integral component of membrane. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and liver and biliary system. Orthologous to human SLC6A12 (solute carrier family 6 member 12). [provided by Alliance of Genome Resources, Apr 2022]

Slc6a12 Products(6)

mRNA Protein Name
NM_001347433.1 NP_001334362.1 sodium- and chloride-dependent betaine transporter isoform 2
NM_001381903.1 NP_001368832.1 sodium- and chloride-dependent betaine transporter isoform 2
NM_001381904.1 NP_001368833.1 sodium- and chloride-dependent betaine transporter isoform 2
NM_001381905.1 NP_001368834.1 sodium- and chloride-dependent betaine transporter isoform 2
NM_001381906.1 NP_001368835.1 sodium- and chloride-dependent betaine transporter isoform 3
NM_133661.3 NP_598422.2 sodium- and chloride-dependent betaine transporter isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables gamma-aminobutyric acid:sodium:chloride symporter activity IDA
IDA: Inferred from direct assay
1517200 MGI
Biological Process GO Annotation Evidence Reference Source
involved in gamma-aminobutyric acid transport IDA
IDA: Inferred from direct assay
1517200 MGI
involved in glycine betaine transport IDA
IDA: Inferred from direct assay
1517200 MGI
Cellular Component GO Annotation Evidence Reference Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
22071246 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
22071246 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sodium- and chloride-dependent betaine transporter

Na(+)/Cl(-) betaine/GABA transporter

gamma-aminobutyric acid (GABA-A) transporter 2

sodium- and chloride-dependent GABA transporter 2

solute carrier family 6 member 12

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13298 SLC6A12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc6a12 NCBI NCBI:6539