B4galnt1 - beta-1,4-N-acetyl-galactosaminyl transferase 1 Gene

Also Known as Ggm2; Ggm-2; Galgt1; GalNAcT; GalNAc-T; Gal-NAc-T; 4933429D13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14421

Summary

Enables (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity. Involved in ganglioside biosynthetic process. Acts upstream of or within glycosphingolipid metabolic process; lipid storage; and spermatogenesis. Predicted to be located in Golgi membrane and plasma membrane. Is expressed in several structures, including alimentary system; eye; genitourinary system; hemolymphoid system; and nervous system. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 26. Orthologous to human B4GALNT1 (beta-1,4-N-acetyl-galactosaminyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

B4galnt1 Products (6)

mRNA Protein Name
NM_001244617.1 NP_001231546.1 beta-1,4 N-acetylgalactosaminyltransferase 1 isoform 3
NM_001244618.1 NP_001231547.1 beta-1,4 N-acetylgalactosaminyltransferase 1 isoform 4
NM_001358577.1 NP_001345506.1 beta-1,4 N-acetylgalactosaminyltransferase 1 isoform 5
NM_001358578.1 NP_001345507.1 beta-1,4 N-acetylgalactosaminyltransferase 1 isoform 6
NM_008080.5 NP_032106.1 beta-1,4 N-acetylgalactosaminyltransferase 1 isoform 1
NM_027739.2 NP_082015.2 beta-1,4 N-acetylgalactosaminyltransferase 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity IMP
IMP: Inferred from mutant phenotype
8855236 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within determination of adult lifespan IGI
IGI: Inferred from genetic interaction
22867887 MGI
acts upstream of or within ganglioside biosynthetic process IGI
IGI: Inferred from genetic interaction
10021458 MGI
acts upstream of or within ganglioside biosynthetic process IMP
IMP: Inferred from mutant phenotype
10021458 MGI
involved in ganglioside biosynthetic process IMP
IMP: Inferred from mutant phenotype
8855236 MGI
acts upstream of or within glycosphingolipid metabolic process IMP
IMP: Inferred from mutant phenotype
18308723 MGI
acts upstream of or within limb development IGI
IGI: Inferred from genetic interaction
22867887 MGI
acts upstream of or within lipid storage IGI
IGI: Inferred from genetic interaction
10021458 MGI
acts upstream of or within motor behavior IGI
IGI: Inferred from genetic interaction
22867887 MGI
acts upstream of or within nerve development IGI
IGI: Inferred from genetic interaction
22867887 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
18308723 MGI
acts upstream of or within vacuole organization IGI
IGI: Inferred from genetic interaction
22867887 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

beta-1,4 N-acetylgalactosaminyltransferase 1

  • (N-acetylneuraminyl)-galactosylglucosylceramide

  • GM2/GD2 synthase

  • UDP-N-acetyl-alpha-D-galactosamine:(N-acetylneuraminyl)-galactosylglucosylceramide-beta-1, 4-N-acetylgalactosaminyltransferase

  • beta1,4GalNAC-T

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01315 B4GALNT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens B4galnt1 NCBI NCBI:2583