Gata5 - GATA binding protein 5 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14464

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including heart development; positive regulation of Notch signaling pathway involved in heart induction; and regulation of gene expression. Acts upstream of or within cellular response to BMP stimulus and positive regulation of transcription, DNA-templated. Located in chromatin. Is expressed in several structures, including branchial arch; genitourinary system; gut; heart; and respiratory system. Used to study essential hypertension. Orthologous to human GATA5 (GATA binding protein 5). [provided by Alliance of Genome Resources, Apr 2022]

Gata5 Products (1)

mRNA Protein Name
NM_008093.2 NP_032119.2 transcription factor GATA-5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
9119112 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15987774 MGI
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
20855530 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14550786 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
9119112 MGI
Biological Process GO Annotation Evidence References Source
involved in aortic valve morphogenesis IMP
IMP: Inferred from mutant phenotype
21633169 MGI
NOT involved in cardiac jelly development IMP
IMP: Inferred from mutant phenotype
21633169 MGI
acts upstream of or within cellular response to BMP stimulus IDA
IDA: Inferred from direct assay
20501701 MGI
involved in endocardial cushion fusion IMP
IMP: Inferred from mutant phenotype
21633169 MGI
involved in heart development IDA
IDA: Inferred from direct assay
21633169 MGI
involved in heart induction IMP
IMP: Inferred from mutant phenotype
21633169 MGI
involved in negative regulation of cardiac muscle hypertrophy IMP
IMP: Inferred from mutant phenotype
21633169 MGI
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
21633169 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
9119112 MGI
involved in positive regulation of Notch signaling pathway IMP
IMP: Inferred from mutant phenotype
21633169 MGI
involved in positive regulation of cardiac endothelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
21633169 MGI
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
21633169 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
21633169 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
9738004 MGI
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
21633169 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor GATA-5

  • GATA-binding factor 5

  • Transcription factor GATA-5 (GATA binding factor-5)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05293 GATA5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gata5 NCBI NCBI:140628