Gata5 - GATA binding protein 5 Gene

Mus musculus

Gene ID: 14464 | Gene type: protein coding

About Gata5

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including heart development; positive regulation of Notch signaling pathway involved in heart induction; and regulation of gene expression. Acts upstream of or within cellular response to BMP stimulus and positive regulation of transcription, DNA-templated. Located in chromatin. Is expressed in several structures, including branchial arch; genitourinary system; gut; heart; and respiratory system. Used to study essential hypertension. Orthologous to human GATA5 (GATA binding protein 5). [provided by Alliance of Genome Resources, Apr 2022]

Gata5 Products(1)

mRNA	Protein	Name
NM_008093.2	NP_032119.2	transcription factor GATA-5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	9119112	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15987774	MGI
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20855530	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14550786	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	9119112	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in aortic valve morphogenesis	IMP IMP: Inferred from mutant phenotype	21633169	MGI
NOT involved in cardiac jelly development	IMP IMP: Inferred from mutant phenotype	21633169	MGI
acts upstream of or within cellular response to BMP stimulus	IDA IDA: Inferred from direct assay	20501701	MGI
involved in endocardial cushion fusion	IMP IMP: Inferred from mutant phenotype	21633169	MGI
involved in heart development	IDA IDA: Inferred from direct assay	21633169	MGI
involved in heart induction	IMP IMP: Inferred from mutant phenotype	21633169	MGI
involved in negative regulation of cardiac muscle hypertrophy	IMP IMP: Inferred from mutant phenotype	21633169	MGI
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	21633169	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9119112	MGI
involved in positive regulation of Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	21633169	MGI
involved in positive regulation of cardiac endothelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	21633169	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	21633169	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21633169	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9738004	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	21633169	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcription factor GATA-5

GATA-binding factor 5

Transcription factor GATA-5 (GATA binding factor-5)

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05293	GATA5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gata5	NCBI	NCBI:140628

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