Gbp2b - guanylate binding protein 2b Gene

Also Known as Gbp1; Mpa1; Gbp-1; Mag-1; Mpa-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14468

Summary

Enables GMP binding activity. Acts upstream of or within adhesion of symbiont to host; cellular response to interferon-beta; and defense response to Other organism. Located in cytoplasmic vesicle and symbiont-containing vacuole membrane. Orthologous to human GBP2 (guanylate binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Gbp2b Products (1)

mRNA Protein Name
NM_010259.2 NP_034389.2 guanylate-binding protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GMP binding IDA
IDA: Inferred from direct assay
3927587 MGI
enables GTPase activity IMP
IMP: Inferred from mutant phenotype
21551061 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21551061 MGI
Biological Process GO Annotation Evidence References Source
involved in activation of innate immune response IMP
IMP: Inferred from mutant phenotype
24739961 MGI
acts upstream of or within adhesion of symbiont to host IDA
IDA: Inferred from direct assay
18025219 MGI
acts upstream of or within cellular response to interferon-beta IDA
IDA: Inferred from direct assay
19158679 MGI
involved in cellular response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
24715728 MGI
acts upstream of or within cellular response to type II interferon IDA
IDA: Inferred from direct assay
18025219 MGI
involved in cytolysis in another organism IMP
IMP: Inferred from mutant phenotype
24715728 MGI
acts upstream of or within defense response to Gram-positive bacterium IDA
IDA: Inferred from direct assay
18025219 MGI
acts upstream of or within defense response to Gram-positive bacterium IMP
IMP: Inferred from mutant phenotype
21551061 MGI
involved in defense response to bacterium IMP
IMP: Inferred from mutant phenotype
24715728 MGI
acts upstream of or within defense response to protozoan IDA
IDA: Inferred from direct assay
18025219 MGI
involved in positive regulation of pyroptotic inflammatory response IMP
IMP: Inferred from mutant phenotype
24715728 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
18025219 MGI
located in symbiont-containing vacuole membrane IDA
IDA: Inferred from direct assay
18025219 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

guanylate-binding protein 1

  • GTP-binding protein 1

  • guanylate nucleotide binding protein 1

  • interferon-gamma-inducible protein MAG-1

  • interferon-induced guanylate-binding protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05308 GBP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P5695 GP-2B Inhibitor / Unkown
HY-RS17953 Gbp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24424 Gbp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown