Gbp2b - guanylate binding protein 2b Gene

Mus musculus

Also known as Gbp1; Mpa1; Gbp-1; Mag-1; Mpa-1

Gene ID: 14468 | Gene type: protein coding

About Gbp2b

Summary

Enables GMP binding activity. Acts upstream of or within adhesion of symbiont to host; cellular response to interferon-beta; and defense response to Other organism. Located in cytoplasmic vesicle and symbiont-containing vacuole membrane. Orthologous to human GBP2 (guanylate binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Gbp2b Products(1)

mRNA	Protein	Name
NM_010259.2	NP_034389.2	guanylate-binding protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GMP binding	IDA IDA: Inferred from direct assay	3927587	MGI
enables GTPase activity	IMP IMP: Inferred from mutant phenotype	21551061	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21551061	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of innate immune response	IMP IMP: Inferred from mutant phenotype	24739961	MGI
acts upstream of or within adhesion of symbiont to host	IDA IDA: Inferred from direct assay	18025219	MGI
acts upstream of or within cellular response to interferon-beta	IDA IDA: Inferred from direct assay	19158679	MGI
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	24715728	MGI
acts upstream of or within cellular response to type II interferon	IDA IDA: Inferred from direct assay	18025219	MGI
involved in cytolysis in another organism	IMP IMP: Inferred from mutant phenotype	24715728	MGI
acts upstream of or within defense response to Gram-positive bacterium	IDA IDA: Inferred from direct assay	18025219	MGI
acts upstream of or within defense response to Gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	21551061	MGI
involved in defense response to bacterium	IMP IMP: Inferred from mutant phenotype	24715728	MGI
acts upstream of or within defense response to protozoan	IDA IDA: Inferred from direct assay	18025219	MGI
involved in positive regulation of pyroptotic inflammatory response	IMP IMP: Inferred from mutant phenotype	24715728	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	18025219	MGI
located in symbiont-containing vacuole membrane	IDA IDA: Inferred from direct assay	18025219	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

guanylate-binding protein 1

GTP-binding protein 1	guanylate nucleotide binding protein 1
interferon-gamma-inducible protein MAG-1	interferon-induced guanylate-binding protein 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05308	GBP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-P5695	GP-2B	Inhibitor	/	Unkown
HY-RS17953	Gbp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24424	Gbp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

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