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Gbx2 - gastrulation brain homeobox 2 Gene

Also Known as Gbx-2; MMoxA; Stra7; D130058E05Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 14472

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II core promoter sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Acts upstream of or within several processes, including branching involved in blood vessel morphogenesis; nervous system development; and neural crest cell migration. Located in nucleus. Is expressed in several structures, including 1st branchial arch; central nervous system; ear; embryo ectoderm; and reproductive system. Orthologous to human GBX2 (gastrulation brain homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Gbx2 Products (1)

mRNA	Protein	Name
NM_010262.3	NP_034392.1	homeobox protein GBX-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	23144817	MGI
enables RNA polymerase II core promoter sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23144817	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23144817	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IDA IDA: Inferred from direct assay	23144817	MGI

Biological Process GO Annotation	Evidence	Verweise	Source
acts upstream of or within autonomic nervous system development	IMP IMP: Inferred from mutant phenotype	15996652	MGI
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	11967891	MGI
acts upstream of or within branching involved in blood vessel morphogenesis	IGI IGI: Inferred from genetic interaction	15996652	MGI
acts upstream of or within branching involved in blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	15996652	MGI
acts upstream of or within cerebellar granule cell precursor proliferation	IMP IMP: Inferred from mutant phenotype	16651541	MGI
acts upstream of or within cerebellum development	IMP IMP: Inferred from mutant phenotype	16651541	MGI
acts upstream of or within forebrain neuron development	IMP IMP: Inferred from mutant phenotype	21048141	MGI
acts upstream of or within hindbrain development	IMP IMP: Inferred from mutant phenotype	15829521	MGI
acts upstream of or within inner ear morphogenesis	IMP IMP: Inferred from mutant phenotype	15829521	MGI
acts upstream of or within midbrain-hindbrain boundary development	IMP IMP: Inferred from mutant phenotype	16651541	MGI
acts upstream of or within midbrain-hindbrain boundary morphogenesis	IMP IMP: Inferred from mutant phenotype	16651541	MGI
acts upstream of or within neural crest cell migration	IMP IMP: Inferred from mutant phenotype	15996652	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	23144817	MGI
acts upstream of or within rhombomere 2 development	IMP IMP: Inferred from mutant phenotype	16651541	MGI
acts upstream of or within thalamus development	IMP IMP: Inferred from mutant phenotype	19279136	MGI
acts upstream of or within tube morphogenesis	IMP IMP: Inferred from mutant phenotype	15996652	MGI

Cellular Component GO Annotation	Evidence	Verweise	Source
located in nucleus	IDA IDA: Inferred from direct assay	23144817	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
homeobox protein GBX-2	gastrulation and brain-specific homeobox protein 2 stimulated by retinoic acid gene 7 protein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS05315	GBX2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gbx2	NCBI	NCBI:2637