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Gja5 - gap junction protein, alpha 5 Gene

Also Known as Cx40; Cxni; Cnx40; Gja-5; 5730555N10Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 14613

Summary

Enables gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling. Involved in artery morphogenesis; cell communication by electrical coupling involved in cardiac conduction; and regulation of cardiac muscle cell action potential. Acts upstream of or within several processes, including cardiac conduction; circulatory system development; and regulation of membrane depolarization. Located in gap junction. Is expressed in several structures, including cardiovascular system; early conceptus; limb mesenchyme; musculature; and skin. Used to study tetralogy of Fallot. Human ortholog(s) of this gene implicated in atrial fibrillation; atrial standstill 1; familial atrial fibrillation; and tetralogy of Fallot. Orthologous to human GJA5 (Gap Junction Protein alpha 5). [provided by Alliance of Genome Resources, Apr 2022]

Gja5 Products (2)

mRNA	Protein	Name
NM_001271628.1	NP_001258557.1	gap junction alpha-5 protein
NM_008121.3	NP_032147.1	gap junction alpha-5 protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling	IMP IMP: Inferred from mutant phenotype	26786475	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within AV node cell to bundle of His cell communication	IMP IMP: Inferred from mutant phenotype	10515563	MGI
involved in AV node cell to bundle of His cell communication by electrical coupling	IMP IMP: Inferred from mutant phenotype	10515563	MGI
acts upstream of or within SA node cell action potential	IMP IMP: Inferred from mutant phenotype	11046183	MGI
involved in artery morphogenesis	IMP IMP: Inferred from mutant phenotype	20530546	MGI
involved in atrial cardiac muscle cell to AV node cell communication by electrical coupling	IMP IMP: Inferred from mutant phenotype	10515563	MGI
acts upstream of or within atrial septum morphogenesis	IMP IMP: Inferred from mutant phenotype	10969038	MGI
acts upstream of or within atrial ventricular junction remodeling	IMP IMP: Inferred from mutant phenotype	10969038	MGI
acts upstream of or within blood vessel development	IMP IMP: Inferred from mutant phenotype	12435353	MGI
acts upstream of or within blood vessel diameter maintenance	IMP IMP: Inferred from mutant phenotype	10747000	MGI
involved in bundle of His cell to Purkinje myocyte communication by electrical coupling	IMP IMP: Inferred from mutant phenotype	26786475	MGI
acts upstream of or within cardiac conduction	IMP IMP: Inferred from mutant phenotype	9501069	MGI
acts upstream of or within cardiac conduction system development	IMP IMP: Inferred from mutant phenotype	18599871	MGI
acts upstream of or within cell communication by electrical coupling involved in cardiac conduction	IMP IMP: Inferred from mutant phenotype	11046183	MGI
acts upstream of or within cell communication involved in cardiac conduction	IMP IMP: Inferred from mutant phenotype	10747000	MGI
acts upstream of or within embryonic heart tube development	IMP IMP: Inferred from mutant phenotype	14732399	MGI
acts upstream of or within embryonic limb morphogenesis	IMP IMP: Inferred from mutant phenotype	15923624	MGI
acts upstream of or within foramen ovale closure	IMP IMP: Inferred from mutant phenotype	10969038	MGI
involved in regulation of AV node cell action potential	IMP IMP: Inferred from mutant phenotype	10515563	MGI
acts upstream of or within regulation of atrial cardiac muscle cell membrane depolarization	IMP IMP: Inferred from mutant phenotype	9501070	MGI
involved in regulation of bundle of His cell action potential	IMP IMP: Inferred from mutant phenotype	10515563	MGI
acts upstream of or within regulation of heart rate by cardiac conduction	IMP IMP: Inferred from mutant phenotype	11046183	MGI
acts upstream of or within regulation of membrane depolarization during cardiac muscle cell action potential	IMP IMP: Inferred from mutant phenotype	9501070	MGI
acts upstream of or within regulation of renin secretion into blood stream	IMP IMP: Inferred from mutant phenotype	17255527	MGI
acts upstream of or within regulation of systemic arterial blood pressure	IMP IMP: Inferred from mutant phenotype	10747000	MGI
acts upstream of or within regulation of ventricular cardiac muscle cell membrane depolarization	IGI IGI: Inferred from genetic interaction	10969038	MGI
acts upstream of regulation of ventricular cardiac muscle cell membrane depolarization	IMP IMP: Inferred from mutant phenotype	26786475	MGI
acts upstream of or within regulation of ventricular cardiac muscle cell membrane depolarization	IMP IMP: Inferred from mutant phenotype	9501070	MGI
acts upstream of or within regulation of ventricular cardiac muscle cell membrane repolarization	IGI IGI: Inferred from genetic interaction	10969038	MGI
acts upstream of regulation of ventricular cardiac muscle cell membrane repolarization	IMP IMP: Inferred from mutant phenotype	26786475	MGI
acts upstream of or within regulation of ventricular cardiac muscle cell membrane repolarization	IMP IMP: Inferred from mutant phenotype	10969038	MGI
acts upstream of or within renal system process involved in regulation of systemic arterial blood pressure	IMP IMP: Inferred from mutant phenotype	17255527	MGI
acts upstream of or within septum primum development	IMP IMP: Inferred from mutant phenotype	10969038	MGI
acts upstream of or within skeletal system development	IMP IMP: Inferred from mutant phenotype	15923624	MGI
acts upstream of or within ventricular cardiac muscle cell action potential	IMP IMP: Inferred from mutant phenotype	9501070	MGI
acts upstream of or within ventricular septum morphogenesis	IMP IMP: Inferred from mutant phenotype	10969038	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in gap junction	IDA IDA: Inferred from direct assay	9501070	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
gap junction alpha-5 protein	connexin i connexin-40 gap junction membrane channel protein alpha 5

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05444	GJA5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gja5	NCBI	NCBI:2702