Gna12 - guanine nucleotide binding protein, alpha 12 Gene

Also Known as Galpha12

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14673

Summary

Predicted to enable D5 Dopamine Receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in several processes, including multicellular organism aging; regulation of TOR signaling; and regulation of fibroblast migration. Acts upstream of or within several processes, including Rho protein signal transduction; embryonic digit morphogenesis; and regulation of cell shape. Predicted to be located in cytoplasm and plasma membrane. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in brush border membrane. Is expressed in several structures, including branchial arch; central nervous system; female reproductive system; heart; and retina. Orthologous to human GNA12 (G protein subunit alpha 12). [provided by Alliance of Genome Resources, Apr 2022]

Gna12 Products (1)

mRNA Protein Name
NM_010302.2 NP_034432.1 guanine nucleotide-binding protein subunit alpha-12

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within Rho protein signal transduction IDA
IDA: Inferred from direct assay
10037795 MGI
acts upstream of or within cell differentiation IDA
IDA: Inferred from direct assay
9305907 MGI
acts upstream of or within embryonic digit morphogenesis IGI
IGI: Inferred from genetic interaction
12077299 MGI
acts upstream of or within in utero embryonic development IGI
IGI: Inferred from genetic interaction
12077299 MGI
acts upstream of or within intracellular signal transduction IDA
IDA: Inferred from direct assay
10037795 MGI
involved in regulation of TOR signaling IMP
IMP: Inferred from mutant phenotype
22609986 MGI
involved in regulation of blood pressure IGI
IGI: Inferred from genetic interaction
26531127 MGI
acts upstream of or within regulation of cell shape IDA
IDA: Inferred from direct assay
10037795 MGI
involved in regulation of fibroblast migration IMP
IMP: Inferred from mutant phenotype
22609986 MGI
involved in regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
22609986 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

guanine nucleotide-binding protein subunit alpha-12

  • G-protein subunit alpha-12

  • g alpha-12

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05530 GNA12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gna12 NCBI NCBI:2768