Gnat1 - G protein subunit alpha transducin 1 Gene

Mus musculus

Also known as Hg1f; Ird1; Ird2; irdc; irdr; Gnat-1; Tralpha; transducin

Gene ID: 14685 | Gene type: protein coding

About Gnat1

Summary

Enables G-protein beta/gamma-subunit complex binding activity and GTPase activity. Acts upstream of or within several processes, including cellular response to electrical stimulus; detection of light stimulus; and eye development. Located in photoreceptor connecting cilium; photoreceptor inner segment; and photoreceptor outer segment. Is expressed in brain; photoreceptor layer outer segment; retina; and retina outer nuclear layer. Human ortholog(s) of this gene implicated in congenital stationary night blindness 1G; congenital stationary night blindness autosomal dominant 3; and night blindness. Orthologous to human GNAT1 (G protein subunit alpha transducin 1). [provided by Alliance of Genome Resources, Apr 2022]

Gnat1 Products(1)

mRNA	Protein	Name
NM_008140.3	NP_032166.1	guanine nucleotide-binding protein G(t) subunit alpha-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G-protein beta/gamma-subunit complex binding	IDA IDA: Inferred from direct assay	17881533	MGI
enables GTPase activity	IDA IDA: Inferred from direct assay	17881533	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17881533	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	14712229	MGI
acts upstream of or within G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15073279	MGI
acts upstream of or within background adaptation	IMP IMP: Inferred from mutant phenotype	24373883	MGI
acts upstream of or within cell population proliferation	IDA IDA: Inferred from direct assay	14712229	MGI
acts upstream of or within cellular response to electrical stimulus	IMP IMP: Inferred from mutant phenotype	21052544	MGI
acts upstream of or within detection of light stimulus	IDA IDA: Inferred from direct assay	19815523	MGI
acts upstream of or within detection of light stimulus	IGI IGI: Inferred from genetic interaction	19815523	MGI
acts upstream of or within detection of light stimulus	IMP IMP: Inferred from mutant phenotype	19815523	MGI
acts upstream of or within detection of light stimulus involved in visual perception	IMP IMP: Inferred from mutant phenotype	18171936	MGI
acts upstream of or within dopamine secretion	IMP IMP: Inferred from mutant phenotype	30799247	MGI
acts upstream of or within eye photoreceptor cell development	IMP IMP: Inferred from mutant phenotype	16249514	MGI
acts upstream of or within neural tissue regeneration	IGI IGI: Inferred from genetic interaction	30111842	MGI
acts upstream of or within phototransduction	IMP IMP: Inferred from mutant phenotype	11095744	MGI
acts upstream of or within response to light intensity	IMP IMP: Inferred from mutant phenotype	20844144	MGI
acts upstream of or within response to light stimulus	IDA IDA: Inferred from direct assay	19815523	MGI
acts upstream of or within response to light stimulus	IGI IGI: Inferred from genetic interaction	19815523	MGI
acts upstream of or within response to light stimulus	IMP IMP: Inferred from mutant phenotype	19815523	MGI
acts upstream of or within response to organic cyclic compound	IMP IMP: Inferred from mutant phenotype	31537864	MGI
acts upstream of or within retina development in camera-type eye	IGI IGI: Inferred from genetic interaction	21124780	MGI
acts upstream of or within retina development in camera-type eye	IMP IMP: Inferred from mutant phenotype	21052544	MGI
acts upstream of or within retinal cone cell differentiation	IDA IDA: Inferred from direct assay	19815523	MGI
acts upstream of or within retinal cone cell differentiation	IGI IGI: Inferred from genetic interaction	19815523	MGI
acts upstream of or within retinal cone cell differentiation	IMP IMP: Inferred from mutant phenotype	19815523	MGI
acts upstream of or within retinal rod cell differentiation	IDA IDA: Inferred from direct assay	19815523	MGI
acts upstream of or within retinal rod cell differentiation	IGI IGI: Inferred from genetic interaction	19815523	MGI
acts upstream of or within retinal rod cell differentiation	IMP IMP: Inferred from mutant phenotype	19815523	MGI
acts upstream of or within sensory perception of umami taste	IMP IMP: Inferred from mutant phenotype	15342734	MGI
acts upstream of or within visual behavior	IMP IMP: Inferred from mutant phenotype	20844144	MGI
acts upstream of or within visual perception	IGI IGI: Inferred from genetic interaction	30111842	MGI
acts upstream of or within visual perception	IMP IMP: Inferred from mutant phenotype	16603466	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in photoreceptor connecting cilium	IDA IDA: Inferred from direct assay	17881533	MGI
located in photoreceptor inner segment	IDA IDA: Inferred from direct assay	31696965	MGI
located in photoreceptor outer segment	IDA IDA: Inferred from direct assay	18367617	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

guanine nucleotide-binding protein G(t) subunit alpha-1

guanine nucleotide binding protein, alpha transducing 1	heterotrimeric guanine nucleotide-binding protein 1f
transducin alpha-1 chain

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05541	GNAT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gnat1	NCBI	NCBI:2779

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