2. Gene
  3. ADRA1B - adrenoceptor alpha 1B Gene

ADRA1B - adrenoceptor alpha 1B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ADRA1; ALPHA1BAR

Gene ID: 147 | Gene type: protein coding

About ADRA1B

Cytogenetic location: 5q33.3 Genomic coordinates (GRCh38): 5:159,865,086-159,989,205 (from NCBI)

This gene has 3 transcripts (splice variants), 265 orthologues and 18 paralogues. Biased expression in spleen (RPKM 2.0), brain (RPKM 1.2) and 10 other tissues.

Summary

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq, Jul 2008]

ADRA1B Products(1)

mRNA Protein Name
NM_000679.4 NP_000670.1 alpha-1B adrenergic receptor

ADRA1B Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (62 - 348)

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  • 520 a.a.
Protein Preferred Names Protein Names

alpha-1B adrenergic receptor

adrenergic, alpha-1B-, receptor

Related Diseases

Diseases Alias
Precocious Puberty, Male-Limited

Testotoxicosis

Familial Male-Limited Precocious Puberty

Leydig Cell Adenoma, Somatic, With Precocious Puberty

FMPP

Familial Testotoxicosis

Sexual Precocity, Familial, Gonadotropin-Independent

Familial Gonadotropin-Independent Male-Limited Sexual Precocity

Male-Limited Precocious Puberty

Pubertas Praecox

Gonadotropin-Independent Familial Sexual Precocity

Testotoxicosis, Familial

Precocious Puberty, Male

Precocious Puberty, Male Limited

Familial Gonadotrophin-Independent Sexual Precocity

Gipp

Gonadotrophin-Independent Precocious Puberty

Precocious Pseudopuberty

Familial Male Precocious Puberty

Precocious Puberty In Males

Puberty, Precocious

Precocious Puberty
Prostatic Hypertrophy

Benign Prostatic Hypertrophy

Prostatic Hyperplasia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00409 ADRA1B Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ADRA1B VGNC VGNC:110489
Rattus norvegicus ADRA1B RGD RGD:2054
Mus musculus ADRA1B MGD MGI:104774
Felis catus ADRA1B VGNC VGNC:102155
Canis familiaris ADRA1B VGNC VGNC:37673
Bos taurus ADRA1B VGNC VGNC:25694