Gnpat - glyceronephosphate O-acyltransferase Gene

Mus musculus

Also known as DHAPAT; D1Ertd819e

Gene ID: 14712 | Gene type: protein coding

About Gnpat

Summary

Enables glycerone-phosphate O-acyltransferase activity. Acts upstream of or within several processes, including cell junction assembly; cerebellum morphogenesis; and ether lipid biosynthetic process. Predicted to be located in mitochondrion and peroxisome. Predicted to be active in mitochondrial membrane and peroxisomal membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study disease of mental health and rhizomelic chondrodysplasia punctata type 2. Human ortholog(s) of this gene implicated in rhizomelic chondrodysplasia punctata type 2. Orthologous to human GNPAT (glyceronephosphate O-acyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Gnpat Products(1)

mRNA	Protein	Name
NM_010322.3	NP_034452.3	dihydroxyacetone phosphate acyltransferase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables catalytic activity	IDA IDA: Inferred from direct assay	10456321	MGI
enables glycerone-phosphate O-acyltransferase activity	IDA IDA: Inferred from direct assay	10395968	MGI
enables glycerone-phosphate O-acyltransferase activity	IMP IMP: Inferred from mutant phenotype	12874108	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11591653	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cerebellum morphogenesis	IMP IMP: Inferred from mutant phenotype	19270340	MGI
acts upstream of or within ether lipid biosynthetic process	IMP IMP: Inferred from mutant phenotype	12874108	MGI
acts upstream of or within membrane organization	IMP IMP: Inferred from mutant phenotype	12874108	MGI
acts upstream of or within myelination	IMP IMP: Inferred from mutant phenotype	19270340	MGI
acts upstream of or within paranodal junction assembly	IMP IMP: Inferred from mutant phenotype	19270340	MGI
acts upstream of or within synapse assembly	IMP IMP: Inferred from mutant phenotype	19270340	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in peroxisome	IDA IDA: Inferred from direct assay	10456321	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

dihydroxyacetone phosphate acyltransferase

DAP-AT	DHAP-AT
acyl-CoA:dihydroxyacetonephosphateacyltransferase	glycerone-phosphate O-acyltransferase

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1465	1-Hexadecanol		99.76%	Unkown

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05570	GNPAT Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gnpat	NCBI	NCBI:8443

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