Gpld1 - glycosylphosphatidylinositol specific phospholipase D1 Gene

Also Known as 6330541J12Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 14756

Summary

Enables glycosylphosphatidylinositol Phospholipase D activity and Sodium Channel regulator activity. Involved in several processes, including positive regulation of high-density lipoprotein particle clearance; positive regulation of Insulin secretion involved in cellular response to glucose stimulus; and regulation of triglyceride metabolic process. Acts upstream of or within GPI anchor release; chondrocyte differentiation; and ossification. Located in several cellular components, including extracellular matrix; extracellular space; and intracellular membrane-bounded organelle. Is expressed in several structures, including alimentary system; central nervous system; ear; genitourinary system; and skeleton. Orthologous to human GPLD1 (glycosylphosphatidylinositol specific Phospholipase D1). [provided by Alliance of Genome Resources, Apr 2022]

Gpld1 Products (1)

mRNA	Protein	Name
NM_008156.2	NP_032182.2	phosphatidylinositol-glycan-specific phospholipase D precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables glycosylphosphatidylinositol phospholipase D activity	IDA IDA: Inferred from direct assay	1833386	MGI
enables phospholipase D activity	IDA IDA: Inferred from direct assay	9716655	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	23055941	MGI
enables sodium channel regulator activity	IMP IMP: Inferred from mutant phenotype	16822939	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within GPI anchor release	IDA IDA: Inferred from direct assay	9716655	MGI
involved in GPI anchor release	IDA IDA: Inferred from direct assay	15946906	MGI
involved in GPI anchor release	IGI IGI: Inferred from genetic interaction	17720976	MGI
involved in chondrocyte differentiation	IEP IEP: Inferred from expression pattern	15946906	MGI
involved in negative regulation of triglyceride catabolic process	IDA IDA: Inferred from direct assay	16219662	MGI
involved in ossification	IEP IEP: Inferred from expression pattern	15946906	MGI
involved in positive regulation of glucose metabolic process	IDA IDA: Inferred from direct assay	20153004	MGI
involved in positive regulation of high-density lipoprotein particle clearance	IMP IMP: Inferred from mutant phenotype	16219662	MGI
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IDA IDA: Inferred from direct assay	20153004	MGI
involved in positive regulation of membrane protein ectodomain proteolysis	IDA IDA: Inferred from direct assay	17720976	MGI
involved in positive regulation of secretion	IMP IMP: Inferred from mutant phenotype	16822939	MGI
involved in positive regulation of triglyceride biosynthetic process	IDA IDA: Inferred from direct assay	16219662	MGI
involved in transepithelial transport	IMP IMP: Inferred from mutant phenotype	16822939	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15946906	MGI
located in extracellular matrix	IDA IDA: Inferred from direct assay	15946906	MGI
located in extracellular region	IDA IDA: Inferred from direct assay	1833386	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	16219662	MGI
located in intracellular membrane-bounded organelle	IDA IDA: Inferred from direct assay	1833386	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
phosphatidylinositol-glycan-specific phospholipase D	GPI-PLD GPI-specific phospholipase D PI-G PLD glycoprotein phospholipase D glycosyl-phosphatidylinositol-specific phospholipase D

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05642	GPLD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20415	Gpld1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26924	Gpld1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gpld1	NCBI	NCBI:2822