Rhpn1 - rhophilin, Rho GTPase binding protein 1 Gene

Also Known as Grbp; Rhophilin; mKIAA1929

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14787

Summary

Acts upstream of or within several processes, including focal adhesion assembly; glomerular filtration; and negative regulation of stress fiber assembly. Located in plasma membrane. Is expressed in several structures, including genitourinary system; hindlimb digit mesenchyme; musculoskeletal system; nervous system; and retina nuclear layer. Orthologous to human RHPN1 (rhophilin Rho GTPase binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Rhpn1 Products (3)

mRNA Protein Name
NM_001163465.2 NP_001156937.1 rhophilin-1 isoform 1
NM_001411251.1 NP_001398180.1 rhophilin-1 isoform 3
NM_008164.3 NP_032190.2 rhophilin-1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
8571126 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within focal adhesion assembly IMP
IMP: Inferred from mutant phenotype
25071083 MGI
acts upstream of or within glomerular filtration IGI
IGI: Inferred from genetic interaction
25071083 MGI
acts upstream of or within glomerular filtration IMP
IMP: Inferred from mutant phenotype
25071083 MGI
acts upstream of or within kidney development IGI
IGI: Inferred from genetic interaction
25071083 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
25071083 MGI
acts upstream of or within negative regulation of stress fiber assembly IDA
IDA: Inferred from direct assay
25071083 MGI
acts upstream of or within plasma membrane bounded cell projection morphogenesis IMP
IMP: Inferred from mutant phenotype
25071083 MGI
acts upstream of or within renal albumin absorption IMP
IMP: Inferred from mutant phenotype
25071083 MGI
Cellular Component GO Annotation Evidence References Source
located in cell periphery IDA
IDA: Inferred from direct assay
25071083 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
25071083 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

rhophilin-1

  • GTP-Rho-binding protein 1

  • GTP-rho binding protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11961 RHPN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rhpn1 NCBI NCBI:114822