CSTF3 - cleavage stimulation factor subunit 3 Gene

Also Known as CSTF-77

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1479

About CSTF3

Cytogenetic location: 11p13 Genomic coordinates (GRCh38): 11:33,084,584-33,161,480 (from NCBI)

This gene has 8 transcripts (splice variants) and 233 orthologues. Ubiquitous expression in testis (RPKM 12.9), lymph node (RPKM 7.3) and 25 other tissues.

Summary

The protein encoded by this gene is one of three (including CSTF1 and CSTF2) cleavage stimulation factors that combine to form the cleavage stimulation factor complex (CSTF). This complex is involved in the polyadenylation and 3' end cleavage of pre-mRNAs. The encoded protein functions as a homodimer and interacts directly with both CSTF1 and CSTF2 in the CSTF complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

CSTF3 Products (3)

mRNA Protein Name
NM_001033505.2 NP_001028677.1 cleavage stimulation factor subunit 3 isoform 2
NM_001033506.2 NP_001028678.1 cleavage stimulation factor subunit 3 isoform 3
NM_001326.3 NP_001317.1 cleavage stimulation factor subunit 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
7590244 GOA
Biological Process GO Annotation Evidence References Source
involved in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway IDA
IDA: Inferred from direct assay
7984242 GOA
Cellular Component GO Annotation Evidence References Source
part of mRNA cleavage stimulating factor complex IDA
IDA: Inferred from direct assay
7984242 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CSTF3 Protein Structure

Suf

Suf: Suppressor of forked protein (Suf) (375 - 649)

  • 0
  • 200
  • 400
  • 600
  • 717 a.a.
Protein Preferred Names Protein Names

cleavage stimulation factor subunit 3

  • CF-1 77 kDa subunit

Related Diseases

Diseases Alias
Oculopharyngeal Muscular Dystrophy

  • OPMD

  • Muscular Dystrophy, Oculopharyngeal

  • Dystrophy, Oculopharyngeal Muscular

  • Oculopharyngeal Dystrophy

  • Progressive Muscular Dystrophy, Oculopharyngeal Type

  • Muscular Dystrophy Oculopharyngeal

  • Dystrophy, Muscular, Oculopharyngeal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03276 CSTF3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CSTF3 VGNC VGNC:39684
Felis catus CSTF3 VGNC VGNC:61241
Macaca mulatta CSTF3 VGNC VGNC:71537
Mus musculus CSTF3 MGD MGI:1351825
Bos taurus CSTF3 VGNC VGNC:27783
Rattus norvegicus CSTF3 RGD RGD:1305901
Others CSTF3 NCBI