Tle5 - TLE family member 5, transcriptional modulator Gene

Also Known as Aes; Grg; Esp1; Grg5; Grg-5

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14797

Summary

This gene encodes a protein that belongs to the Aes (amino-terminal enhancer of split) subgroup of the Groucho/transducin-like Enhancer of split (TLE) family of proteins that function as transcriptional corepressors. The encoded protein plays a role in neurological development and cell-fate determination. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2013]

Tle5 Products (2)

mRNA Protein Name
NM_001276288.1 NP_001263217.1 TLE family member 5 isoform 2
NM_010347.4 NP_034477.1 TLE family member 5 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12050133 MGI
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
12050133 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12050133 MGI
acts upstream of or within regulation of growth IMP
IMP: Inferred from mutant phenotype
11984876 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
16002402 MGI
acts upstream of or within skeletal system development IMP
IMP: Inferred from mutant phenotype
11984876 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
12050133 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

TLE family member 5

  • amino-terminal enhancer of split

  • groucho-related protein 5

  • related to Drosophila groucho

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14567 TLE5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tle5 NCBI NCBI:166