Tle5 - TLE family member 5, transcriptional modulator Gene

Mus musculus

Also known as Aes; Grg; Esp1; Grg5; Grg-5

Gene ID: 14797 | Gene type: protein coding

About Tle5

Summary

This gene encodes a protein that belongs to the Aes (amino-terminal enhancer of split) subgroup of the Groucho/transducin-like Enhancer of split (TLE) family of proteins that function as transcriptional corepressors. The encoded protein plays a role in neurological development and cell-fate determination. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2013]

Tle5 Products(2)

mRNA	Protein	Name
NM_001276288.1	NP_001263217.1	TLE family member 5 isoform 2
NM_010347.4	NP_034477.1	TLE family member 5 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12050133	MGI
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	12050133	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12050133	MGI
acts upstream of or within regulation of growth	IMP IMP: Inferred from mutant phenotype	11984876	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16002402	MGI
acts upstream of or within skeletal system development	IMP IMP: Inferred from mutant phenotype	11984876	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	12050133	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

TLE family member 5

amino-terminal enhancer of split	groucho-related protein 5
related to Drosophila groucho

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14567	TLE5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tle5	NCBI	NCBI:166

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