Gria4 - glutamate receptor, ionotropic, AMPA4 (alpha 4) Gene

Also Known as GluA4; Glur4; spkw1; GluR-D; Glur-4; Gluralpha4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14802

Summary

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008]

Gria4 Products (3)

mRNA Protein Name
NM_001113180.2 NP_001106651.2 glutamate receptor 4 isoform 2 precursor
NM_001113181.1 NP_001106652.1 glutamate receptor 4 isoform 3 precursor
NM_019691.5 NP_062665.4 glutamate receptor 4 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15883194 MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
IDA: Inferred from direct assay
21857658 MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
21857658 MGI
Cellular Component GO Annotation Evidence References Source
part of AMPA glutamate receptor complex IDA
IDA: Inferred from direct assay
15883194 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
21857658 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
21857658 MGI
located in synapse IDA
IDA: Inferred from direct assay
22632720 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutamate receptor 4

  • AMPA-selective glutamate receptor 4

  • glutamate receptor channel alpha 4

  • glutamate receptor ionotropic, AMPA 4

  • spike wave 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05794 GRIA4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gria4 NCBI NCBI:2893