Grid2 - glutamate receptor, ionotropic, delta 2 Gene

Also Known as Lc; ho; cpr; tpr; GluD2; Lc; Ms10ac; nmf408; MMS10-AC; GluRdelta2; B230104L07Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 14804

Summary

Enables PDZ domain binding activity and scaffold protein binding activity. Involved in several processes, including cerebellar granule cell differentiation; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and regulation of postsynaptic density assembly. Acts upstream of or within several processes, including chemical synaptic transmission; prepulse inhibition; and regulation of neuron apoptotic process. Located in dendritic spine and postsynaptic membrane. Part of ionotropic glutamate receptor complex. Is active in glutamatergic synapse and parallel fiber to Purkinje cell synapse. Is integral component of postsynaptic density membrane. Is expressed in several structures, including brain; eye; genitourinary system; intestine; and spinal cord. Used to study autosomal recessive spinocerebellar ataxia 18. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 18. Orthologous to human GRID2 (glutamate ionotropic receptor delta type subunit 2). [provided by Alliance of Genome Resources, Apr 2022]

Grid2 Products (2)

mRNA	Protein	Name
NM_001370966.1	NP_001357895.1	glutamate receptor ionotropic, delta-2 isoform 2 precursor
NM_008167.3	NP_032193.1	glutamate receptor ionotropic, delta-2 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	15207857	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11826110	MGI
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	15207857	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in cerebellar granule cell differentiation	IGI IGI: Inferred from genetic interaction	20537373	MGI
acts upstream of or within excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	7766857	MGI
involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IGI IGI: Inferred from genetic interaction	20537373	MGI
acts upstream of or within prepulse inhibition	IMP IMP: Inferred from mutant phenotype	11488959	MGI
involved in protein localization	IDA IDA: Inferred from direct assay	15207857	MGI
acts upstream of or within regulation of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	10884318	MGI
acts upstream of or within regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	10884318	MGI
acts upstream of or within regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	7891151	MGI
involved in regulation of postsynaptic density assembly	IDA IDA: Inferred from direct assay	20395510	MGI
involved in regulation of postsynaptic density assembly	IMP IMP: Inferred from mutant phenotype	20395510	MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA IDA: Inferred from direct assay	34135511	MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IMP IMP: Inferred from mutant phenotype	34135511	MGI
acts upstream of or within synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	7766857	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in dendritic spine	IDA IDA: Inferred from direct assay	15207857	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	20395510	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	20395510	MGI
part of ionotropic glutamate receptor complex	IDA IDA: Inferred from direct assay	15207857	MGI
located in membrane	IDA IDA: Inferred from direct assay	15579147	MGI
is active in parallel fiber to Purkinje cell synapse	IDA IDA: Inferred from direct assay	20395510	MGI
is active in parallel fiber to Purkinje cell synapse	IMP IMP: Inferred from mutant phenotype	20395510	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15207857	MGI
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	20395510	MGI
is active in postsynaptic density membrane	IMP IMP: Inferred from mutant phenotype	20395510	MGI
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	15207857	MGI
located in somatodendritic compartment	IDA IDA: Inferred from direct assay	18341993	MGI
located in synapse	IDA IDA: Inferred from direct assay	12372286	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
glutamate receptor ionotropic, delta-2	creeper gluR delta-2 subunit glutamate receptor delta-2 subunit hotfoot lurcher minisatellite 10ac detected by probe MMS10

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05796	GRID2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grid2	NCBI	NCBI:2895