Grin2d - glutamate receptor, ionotropic, NMDA2D (epsilon 4) Gene

Mus musculus

Also known as NR2D; GluN2D; NMDAR2D

Gene ID: 14814 | Gene type: protein coding

About Grin2d

Summary

Enables NMDA glutamate receptor activity. Acts upstream of or within adult locomotory behavior; regulation of sensory perception of pain; and startle response. Located in synapse. Is expressed in brain. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 46. Orthologous to human GRIN2D (glutamate ionotropic receptor NMDA type subunit 2D). [provided by Alliance of Genome Resources, Apr 2022]

Grin2d Products(1)

mRNA	Protein	Name
NM_008172.3	NP_032198.2	glutamate receptor ionotropic, NMDA 2D precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables NMDA glutamate receptor activity	IDA IDA: Inferred from direct assay	1385220	MGI
enables NMDA glutamate receptor activity	IMP IMP: Inferred from mutant phenotype	12832518	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within adult locomotory behavior	IMP IMP: Inferred from mutant phenotype	8774946	MGI
NOT acts upstream of or within detection of mechanical stimulus involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	16190898	MGI
NOT acts upstream of or within excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	12832518	MGI
acts upstream of or within regulation of sensory perception of pain	IMP IMP: Inferred from mutant phenotype	10771345	MGI
acts upstream of or within startle response	IMP IMP: Inferred from mutant phenotype	9718984	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in synapse	IDA IDA: Inferred from direct assay	8774946	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glutamate receptor ionotropic, NMDA 2D

GluRepsilon4	N-methyl D-aspartate receptor subtype 2D
glur epsilon 4	glutamate [NMDA] receptor subunit epsilon-4
ionotropic NMDA glutamate receptor epsilon 4 subunit type 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05805	GRIN2D Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grin2d	NCBI	NCBI:2906

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