Gsx1 - GS homeobox 1 Gene

Mus musculus

Also known as Gsh1; Gsh-1

Gene ID: 14842 | Gene type: protein coding

About Gsx1

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within nervous system development. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human GSX1 (GS homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Gsx1 Products(1)

mRNA	Protein	Name
NM_008178.3	NP_032204.1	GS homeobox 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11731616	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	11731616	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11731616	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8589431	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within adenohypophysis development	IMP IMP: Inferred from mutant phenotype	8631293	MGI
acts upstream of or within hypothalamus development	IMP IMP: Inferred from mutant phenotype	8631293	MGI
acts upstream of or within neuron fate commitment	IGI IGI: Inferred from genetic interaction	16715081	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11731616	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	8631293	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	11731616	MGI
acts upstream of or within spinal cord association neuron differentiation	IGI IGI: Inferred from genetic interaction	16715081	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	8631293	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

GS homeobox 1

genomic screened homeo box 1

homeobox protein GSH-1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05890	GSX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gsx1	NCBI	NCBI:219409

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