Gsx2 - GS homeobox 2 Gene

Also Known as Gsh2; Gsh-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14843

Summary

Enables DNA binding activity. Acts upstream of or within several processes, including nervous system development; positive regulation of Notch signaling pathway; and regulation of respiratory gaseous exchange by nervous system process. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; genitourinary system; and neural ectoderm. Orthologous to human GSX2 (GS homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Gsx2 Products (1)

mRNA Protein Name
NM_133256.2 NP_573555.1 GS homeobox 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
7619729 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within GABAergic neuron differentiation IMP
IMP: Inferred from mutant phenotype
11060228 MGI
acts upstream of Notch signaling pathway IMP
IMP: Inferred from mutant phenotype
23042297 MGI
acts upstream of or within brain development IGI
IGI: Inferred from genetic interaction
12930780 MGI
acts upstream of or within central nervous system development IMP
IMP: Inferred from mutant phenotype
11731457 MGI
acts upstream of or within forebrain dorsal/ventral pattern formation IMP
IMP: Inferred from mutant phenotype
11060228 MGI
acts upstream of or within forebrain morphogenesis IMP
IMP: Inferred from mutant phenotype
9398437 MGI
involved in generation of neurons IMP
IMP: Inferred from mutant phenotype
28814342 MGI
acts upstream of or within hindbrain morphogenesis IMP
IMP: Inferred from mutant phenotype
9398437 MGI
acts upstream of or within neuron fate commitment IGI
IGI: Inferred from genetic interaction
16715081 MGI
acts upstream of or within neuron fate specification IMP
IMP: Inferred from mutant phenotype
15930101 MGI
involved in olfactory bulb development IMP
IMP: Inferred from mutant phenotype
28814342 MGI
acts upstream of or within olfactory bulb interneuron differentiation IMP
IMP: Inferred from mutant phenotype
11060228 MGI
acts upstream of or within pattern specification process IGI
IGI: Inferred from genetic interaction
12930780 MGI
acts upstream of or within pattern specification process IMP
IMP: Inferred from mutant phenotype
11731457 MGI
acts upstream of or within positive regulation of Notch signaling pathway IMP
IMP: Inferred from mutant phenotype
23042297 MGI
acts upstream of or within positive regulation of oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
23042297 MGI
acts upstream of or within regulation of cell migration IMP
IMP: Inferred from mutant phenotype
18701439 MGI
acts upstream of or within regulation of respiratory gaseous exchange by nervous system process IMP
IMP: Inferred from mutant phenotype
9398437 MGI
acts upstream of or within spinal cord association neuron differentiation IGI
IGI: Inferred from genetic interaction
16715081 MGI
acts upstream of or within subpallium development IGI
IGI: Inferred from genetic interaction
23042297 MGI
acts upstream of or within subpallium neuron fate commitment IMP
IMP: Inferred from mutant phenotype
11124115 MGI
acts upstream of or within telencephalon regionalization IMP
IMP: Inferred from mutant phenotype
18701439 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

GS homeobox 2

  • genetic-screened homeobox 2

  • genomic screened homeo box 2

  • homeobox protein GSH-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05891 GSX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gsx2 NCBI NCBI:170825