Gsx2 - GS homeobox 2 Gene

Mus musculus

Also known as Gsh2; Gsh-2

Gene ID: 14843 | Gene type: protein coding

About Gsx2

Summary

Enables DNA binding activity. Acts upstream of or within several processes, including nervous system development; positive regulation of Notch signaling pathway; and regulation of respiratory gaseous exchange by nervous system process. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; genitourinary system; and neural ectoderm. Orthologous to human GSX2 (GS homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Gsx2 Products(1)

mRNA	Protein	Name
NM_133256.2	NP_573555.1	GS homeobox 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	7619729	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within GABAergic neuron differentiation	IMP IMP: Inferred from mutant phenotype	11060228	MGI
acts upstream of Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	23042297	MGI
acts upstream of or within brain development	IGI IGI: Inferred from genetic interaction	12930780	MGI
acts upstream of or within central nervous system development	IMP IMP: Inferred from mutant phenotype	11731457	MGI
acts upstream of or within forebrain dorsal/ventral pattern formation	IMP IMP: Inferred from mutant phenotype	11060228	MGI
acts upstream of or within forebrain morphogenesis	IMP IMP: Inferred from mutant phenotype	9398437	MGI
involved in generation of neurons	IMP IMP: Inferred from mutant phenotype	28814342	MGI
acts upstream of or within hindbrain morphogenesis	IMP IMP: Inferred from mutant phenotype	9398437	MGI
acts upstream of or within neuron fate commitment	IGI IGI: Inferred from genetic interaction	16715081	MGI
acts upstream of or within neuron fate specification	IMP IMP: Inferred from mutant phenotype	15930101	MGI
involved in olfactory bulb development	IMP IMP: Inferred from mutant phenotype	28814342	MGI
acts upstream of or within olfactory bulb interneuron differentiation	IMP IMP: Inferred from mutant phenotype	11060228	MGI
acts upstream of or within pattern specification process	IGI IGI: Inferred from genetic interaction	12930780	MGI
acts upstream of or within pattern specification process	IMP IMP: Inferred from mutant phenotype	11731457	MGI
acts upstream of or within positive regulation of Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	23042297	MGI
acts upstream of or within positive regulation of oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	23042297	MGI
acts upstream of or within regulation of cell migration	IMP IMP: Inferred from mutant phenotype	18701439	MGI
acts upstream of or within regulation of respiratory gaseous exchange by nervous system process	IMP IMP: Inferred from mutant phenotype	9398437	MGI
acts upstream of or within spinal cord association neuron differentiation	IGI IGI: Inferred from genetic interaction	16715081	MGI
acts upstream of or within subpallium development	IGI IGI: Inferred from genetic interaction	23042297	MGI
acts upstream of or within subpallium neuron fate commitment	IMP IMP: Inferred from mutant phenotype	11124115	MGI
acts upstream of or within telencephalon regionalization	IMP IMP: Inferred from mutant phenotype	18701439	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

GS homeobox 2

genetic-screened homeobox 2	genomic screened homeo box 2
homeobox protein GSH-2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05891	GSX2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gsx2	NCBI	NCBI:170825

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