Nkx6-2 - NK6 homeobox 2 Gene

Mus musculus

Also known as Gtx; Nkx6.2

Gene ID: 14912 | Gene type: protein coding

About Nkx6-2

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription, DNA-templated and regulation of myelination. Acts upstream of or within several processes, including negative regulation of transcription by RNA polymerase II; neurogenesis; and neuromuscular process controlling balance. Located in nucleus. Is expressed in several structures, including 4-cell stage embryo; central nervous system; gut; neural ectoderm; and thymus. Human ortholog(s) of this gene implicated in spastic ataxia 8. Orthologous to human NKX6-2 (NK6 homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Nkx6-2 Products(2)

mRNA	Protein	Name
NM_183248.4	NP_899071.2	homeobox protein Nkx-6.2
NM_183248.4	NP_899071.2	homeobox protein Nkx-6.2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	8096811	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8096811	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of cell fate commitment	IMP IMP: Inferred from mutant phenotype	11567614	MGI
acts upstream of or within central nervous system myelination	IMP IMP: Inferred from mutant phenotype	15601927	MGI
acts upstream of or within endocrine pancreas development	IGI IGI: Inferred from genetic interaction	15944193	MGI
acts upstream of or within negative regulation of cell fate commitment	IMP IMP: Inferred from mutant phenotype	11567614	MGI
acts upstream of or within negative regulation of oligodendrocyte differentiation	IGI IGI: Inferred from genetic interaction	15629702	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8096811	MGI
acts upstream of or within neuromuscular process controlling balance	IMP IMP: Inferred from mutant phenotype	15601927	MGI
acts upstream of neuron fate commitment	IMP IMP: Inferred from mutant phenotype	11567614	MGI
acts upstream of oligodendrocyte differentiation	IGI IGI: Inferred from genetic interaction	15629702	MGI
acts upstream of or within oligodendrocyte differentiation	IGI IGI: Inferred from genetic interaction	15629701	MGI
acts upstream of or within pancreatic A cell differentiation	IGI IGI: Inferred from genetic interaction	15944193	MGI
acts upstream of or within positive regulation of cell fate commitment	IMP IMP: Inferred from mutant phenotype	11567614	MGI
acts upstream of or within positive regulation of oligodendrocyte differentiation	IGI IGI: Inferred from genetic interaction	15629702	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	11567614	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	11567614	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	11567614	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

homeobox protein Nkx-6.2

Drosophila NK transcription factor related, gene family 6, locus 2	NK6 transcription factor related, locus 2
glial and testis specific homeobox

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09336	NKX6-2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nkx6-2	NCBI	NCBI:84504

Name
Email *

	Sorry, but the email address you supplied was invalid.