Nkx6-2 - NK6 homeobox 2 Gene

Also Known as Gtx; Nkx6.2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14912

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription, DNA-templated and regulation of myelination. Acts upstream of or within several processes, including negative regulation of transcription by RNA polymerase II; neurogenesis; and neuromuscular process controlling balance. Located in nucleus. Is expressed in several structures, including 4-cell stage embryo; central nervous system; gut; neural ectoderm; and thymus. Human ortholog(s) of this gene implicated in spastic ataxia 8. Orthologous to human NKX6-2 (NK6 homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Nkx6-2 Products (2)

mRNA Protein Name
NM_183248.4 NP_899071.2 homeobox protein Nkx-6.2
NM_183248.4 NP_899071.2 homeobox protein Nkx-6.2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
8096811 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
8096811 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of cell fate commitment IMP
IMP: Inferred from mutant phenotype
11567614 MGI
acts upstream of or within central nervous system myelination IMP
IMP: Inferred from mutant phenotype
15601927 MGI
acts upstream of or within endocrine pancreas development IGI
IGI: Inferred from genetic interaction
15944193 MGI
acts upstream of or within negative regulation of cell fate commitment IMP
IMP: Inferred from mutant phenotype
11567614 MGI
acts upstream of or within negative regulation of oligodendrocyte differentiation IGI
IGI: Inferred from genetic interaction
15629702 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8096811 MGI
acts upstream of or within neuromuscular process controlling balance IMP
IMP: Inferred from mutant phenotype
15601927 MGI
acts upstream of neuron fate commitment IMP
IMP: Inferred from mutant phenotype
11567614 MGI
acts upstream of oligodendrocyte differentiation IGI
IGI: Inferred from genetic interaction
15629702 MGI
acts upstream of or within oligodendrocyte differentiation IGI
IGI: Inferred from genetic interaction
15629701 MGI
acts upstream of or within pancreatic A cell differentiation IGI
IGI: Inferred from genetic interaction
15944193 MGI
acts upstream of or within positive regulation of cell fate commitment IMP
IMP: Inferred from mutant phenotype
11567614 MGI
acts upstream of or within positive regulation of oligodendrocyte differentiation IGI
IGI: Inferred from genetic interaction
15629702 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
11567614 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
11567614 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
11567614 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein Nkx-6.2

  • Drosophila NK transcription factor related, gene family 6, locus 2

  • NK6 transcription factor related, locus 2

  • glial and testis specific homeobox

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09336 NKX6-2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nkx6-2 NCBI NCBI:84504