BNIPL - BCL2 interacting protein like Gene

Also Known as BNIPS; PP753; BNIP-S; BNIPL1; BNIPL2; BNIPL-1; BNIPL-2; BNIP-Sbeta; BNIP-Salpha

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 149428

About BNIPL

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:151,036,586-151,047,720 (from NCBI)

This gene has 7 transcripts (splice variants), 236 orthologues and 3 paralogues. Biased expression in skin (RPKM 64.5), esophagus (RPKM 30.1) and 1 other tissue.

Summary

The protein encoded by this gene interacts with several Other proteins, such as BCL2, ARHGAP1, MIF and GFER. It may function as a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

BNIPL Products (2)

mRNA	Protein	Name
NM_001159642.2	NP_001153114.1	bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein isoform b
NM_138278.4	NP_612122.2	bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	12901880	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12681488	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within apoptotic process	IDA IDA: Inferred from direct assay	11741952	GOA
involved in apoptotic process	IDA IDA: Inferred from direct assay	11741952	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	12681488	GOA
involved in regulation of growth rate	IDA IDA: Inferred from direct assay	12681488	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	11741952	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11741952	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BNIPL Protein Structure

BNIP2

CRAL_TRIO_2

0
100
200
300
357 a.a.

Protein Preferred Names	Protein Names
bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein	BCL2/adenovirus E1B 19kD interacting protein like

Related Diseases

Diseases	Alias
Nephronophthisis 3	NPHP3 Nph3 Adolescent Nephronophthisis Nephronophthisis, Type 3
Verrucous Papilloma
Cerebellopontine Angle Tumor	Cerebellopontine Angle Tumour Neoplasm Of The Cerebellopontine Angle

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01566	BNIPL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	BNIPL	RGD	RGD:1309478
Bos taurus	BNIPL	VGNC	VGNC:26535
Canis familiaris	BNIPL	VGNC	VGNC:38494
Mus musculus	BNIPL	MGD	MGI:2384749
Macaca mulatta	BNIPL	VGNC	VGNC:70329
Felis catus	BNIPL	VGNC	VGNC:80148
Others	BNIPL	NCBI