CTNNA2 - catenin alpha 2 Gene

Homo sapiens

Also known as CAPR; CTNR; CAP-R; CT114; CDCBM9

Gene ID: 1496 | Gene type: protein coding

About CTNNA2

Cytogenetic location: 2p12 Genomic coordinates (GRCh38): 2:79,185,377-80,648,780 (from NCBI)

This gene has 19 transcripts (splice variants), 136 orthologues, 4 paralogues and is associated with 115 phenotypes. Biased expression in brain (RPKM 26.7), testis (RPKM 6.2) and 1 other tissue.

Summary

Enables actin filament binding activity. Involved in negative regulation of Arp2/3 complex-mediated actin nucleation; regulation of neuron migration; and regulation of neuron projection development. Located in cytoplasm. Implicated in complex cortical dysplasia with other brain malformations. [provided by Alliance of Genome Resources, Apr 2022]

CTNNA2 Products(8)

mRNA	Protein	Name
NM_001164883.2	NP_001158355.1	catenin alpha-2 isoform 2
NM_001282597.3	NP_001269526.1	catenin alpha-2 isoform 3
NM_001282598.2	NP_001269527.1	catenin alpha-2 isoform 4
NM_001282599.2	NP_001269528.1	catenin alpha-2 isoform 5
NM_001282600.2	NP_001269529.1	catenin alpha-2 isoform 6
NM_001320810.2	NP_001307739.1	catenin alpha-2 isoform 7
NM_001399737.1	NP_001386666.1	catenin alpha-2 isoform 1
NM_004389.4	NP_004380.2	catenin alpha-2 isoform 1

CTNNA2 Protein Structure

Vinculin

0
200
400
600
800
953 a.a.

Protein Preferred Names

Protein Names

catenin alpha-2

alpha-N-catenin

Related Diseases

Diseases

Alias

Cortical Dysplasia, Complex, With Other Brain Malformations 9

CDCBM9

Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome	Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer
Breast And/Or Ovarian Cancer	Breast And Ovarian Cancer Syndrome
Hboc Syndrome	Hereditary Breast And Ovarian Cancer
Brca1- Brca2-Associated Hboc

Complex Cortical Dysplasia With Other Brain Malformations

Cdcbm	Dysplasia, Cortical, Complex, With Other Brain Malformations
Dysplasia ,Cortical, Complex, With Other Brain Malformations

Cerebellar Hypoplasia

Arrhythmogenic Right Ventricular Cardiomyopathy

Arrhythmogenic Right Ventricular Dysplasia	Arvc
Arvd	Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
Arvc Cardiomyopathy	Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia
Arvd/C	Right Ventricular Dysplasia, Arrhythmogenic
Ventricular Dysplasia, Right, Arrhythmogenic	Cardiomyopathy, Ventricular, Right, Arrhythmogenic
Dysplasia, Arrhythmogenic Right Ventricular

Blepharocheilodontic Syndrome 1

Blepharocheilodontic Syndrome	Bcd Syndrome
Elschnig Syndrome	Clefting, Ectropion, And Conical Teeth
Lagophthalmia With Bilateral Cleft Lip And Palate	Blepharo-Cheilo-Odontic Syndrome
Bcds	Ectropion, Inferior, With Cleft Lip And/Or Palate
Blepharo-Cheilo-Dontic Syndrome	BCDS1
Ectropion Inferior Cleft Lip And Or Palate	Clefting-Ectropion-Conical Teeth Syndrome
Ectropion Inferior-Cleft Lip And/Or Palate Syndrome	Lagophthalmia-Cleft Lip And Palate Syndrome
Blepharocheilodontic Syndrome, Type 1

Cerebral Palsy

Infantile Cerebral Palsy	Mixed Cerebral Palsy
Palsy Cerebral	Palsy, Cerebral
Cerebral Palsy, Mixed

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03303	CTNNA2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CTNNA2	VGNC	VGNC:71543
Rattus norvegicus	CTNNA2	RGD	RGD:1305060
Mus musculus	CTNNA2	MGD	MGI:88275

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